A systematic search for solasodine, an important starting material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliflorum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showed curare like activity yielded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yielded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and excitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity.
Effectively motivating social distancing—keeping a physical distance from others —has become a global public health priority during the COVID-19 pandemic. This cross-country preregistered experiment (n=25,718 in 89 countries) tested hypotheses derived from self-determination theory concerning generalizable positive and negative outcomes of different motivational messages encouraging social distancing. Participants were randomly assigned to three conditions: an autonomy-supportive message promoting reflective choices, a controlling message that was restrictive and shaming, or no message. Results partially supported experimental hypotheses: the controlling message increased defiance relative to the autonomy-supportive message and increased controlled motivation (which itself correlated with more defiance and less long-term behavioural intentions to engage in social distancing) relative to no message, but messages did not influence behavioural intentions. Despite small experimental effects on defiance and motivation (rs= .07 and .10), this work highlights the potential harm of controlling public health messages and potential benefits of autonomy-supportive ones.
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