No abstract

The dominant foliation (S2) in the metapelites of the Southalpine basement, near the western side of the Tertiary Adamello intrusive stock, is a Variscan greenschist facies planar fabric, slightly reworked during thick‐skin Alpine tectonics. S2 is defined by muscovite and chlorite and was formed by decrenulation of pre‐existing foliations, which are confined to metre‐size, less‐deformed domains and defined by biotite and white mica. The pre‐S2 fabric is composite (D1a & D1b) and defined by contrasting amphibolite facies metamorphic assemblages in different residual sites. Cld+BtI+Grt+MsI+Pl+Qtz and St+BtII+Grt+MsII+Pl+Qtz assemblages mark D1a and D1b fabrics respectively; these developed during successive steps of a single, temperature‐prograde polyphase event, rather than during separate tectonometamorphic imprints affecting different tectonic units, later coupled during a D2 greenschist facies stage. Thermobarometric estimates of assemblages formed during D1a, D1b and D2 show a transition from T =480–540 °C (during D1a) to T =570–660 °C (during D1b), corresponding to a slight pressure‐increase from 0.75–0.95 GPa to 0.85–1.15 GPa. D2 greenschist retrogression corresponds to a pressure and temperature decrease (T <400–550 °C and P<0.3–0.4 GPa). This P–T–deformation–time path is inferred to be the result of uplift from a depth of c. 35 km, after Palaeozoic subduction and continental collision; it is consistent with models postulated for other metamorphic units of the Variscan Belt in Europe. This is the first documented example in the Southern Alps of temperature‐prograde metamorphism before Palaeozoic collision.

Hepatitis C virus (HCV) infection has been associated with several renal pathologies, including membranoproliferative and membranous glomerulonephritis. Although the presence of HCV proteins has been reported, there are no data concerning detection of the viral RNA in renal cells from HCV-infected patients with kidney disease. In this report we analysed, by in situ hybridization, the presence of HCV RNA in renal biopsies from 10 patients who were positive for antibodies to HCV (anti-HCV) and serum HCV RNA positive, and from four patients without HCV infection, with different renal disease. HCV RNA was detected in the renal biopsies from all of the 10 HCV-infected patients. Hybridization signals were detected in the tubular and capillary endothelial cells. No hybridization signals were found in the renal biopsies of the four anti-HCV-negative patients. In conclusion, our results demonstrate that HCV RNA is common in kidney cells of patients with renal diseases who are infected with HCV. The presence of HCV RNA is not necessarily associated with a pathogenetic consequence.

Pain perception is decreased by shifting attentional focus away from a threatening event. This attentional analgesia engages parallel descending control pathways from anterior cingulate (ACC) to locus coeruleus, and ACC to periaqueductal grey (PAG) − rostral ventromedial medulla (RVM), indicating possible roles for noradrenergic or opioidergic neuromodulators. To determine which pathway modulates nociceptive activity in humans we used optimized whole brain-spinal cord pharmacological-fMRI (N=39) across three sessions. Noxious thermal forearm stimulation generated somatotopic-activation of dorsal horn (DH, C6 segment) whose activity mirrored attentional pain modulation. Activity in an adjacent cluster reported the interaction between task and noxious stimulus. Effective connectivity analysis revealed that ACC recruits PAG and RVM to modulate spinal cord activity. Blocking endogenous opioids with Naltrexone impairs attentional analgesia and disrupts RVM−DH and ACC−PAG connectivity. Noradrenergic augmentation with Reboxetine did not alter attentional analgesia. Cognitive pain modulation is mediated by opioidergic ACC−PAG−RVM descending control which supresses spinal nociceptive activity.