The i-LIMB hand is a novel upper limb myoelectric prosthetic hand with several joints in the fingers and thumb. This study aimed to determine whether this new device had more functionality than a more conventional myoelectric prosthetic hand with only a single joint between the thumb and two fingers. Therefore, a 45-year-old man with a wrist disarticulation used the i-LIMB hand and the widely used Dynamic Mode Control hand (DMC plus hand) in a test procedure that covered all functional levels of the International Classification of Function (ICF). Functional outcomes of the i-LIMB seemed to be lower than or equal to the DMC plus hand. The patient's satisfaction tended to be in favor of the i-LIMB. Compared to the DMC plus hand, the i-LIMB was more reliable when holding objects but had a lack of power and was less robust. We concluded that the i-LIMB hand has limited additional functionality compared to the DMC plus hand.