<b><i>Background:</i></b> Neuropathological studies indicate concomitant Alzheimer’s disease (AD) pathology in patients with dementia with Lewy bodies (DLB). <b><i>Objectives:</i></b> To measure cerebrospinal fluid (CSF) levels of β-amyloid peptide with 42 amino acids (Aβ<sub>42</sub>), total tau protein (τ<sub>T</sub>), and tau phosphorylated at threonine 181 (τ<sub>P-181</sub>) in 38 patients fulfilling the diagnostic criteria of probable DLB according to the most recent (4th consensus) report. <b><i>Methods:</i></b> Double-sandwich commercial ELISAs (Innotest; Fujirebio, Gent, Belgium) were used for measurements. <b><i>Results:</i></b> According to the current cutoff values of our laboratory, 4 biomarker profiles were noted: abnormal levels of Aβ<sub>42</sub> only (44.7%), full AD profile (39.5%), abnormal levels of τ<sub>T</sub> only (5.3%), and normal levels of all 3 biomarkers (10.5%). AD profile was associated with female sex, older age, lower education, and lower MMSE scores. <b><i>Conclusions:</i></b> Reduction in Αβ<sub>42</sub> in DLB may be more common (>80% of patients) than previously thought, and ∼40% may have the typical CSF AD biomarker profile. AD biochemistry in DLB may be an evolving process showing increasing frequency with disease progression.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.