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In this report, we examined the relationship between mother's breastfeeding history and her risk of breast cancer, in a case-control study in Tunisia between 2006 and 2009. About 400 breast cancer cases and 400 controls were included. Cases and controls were interviewed using a standardized structured questionnaire to obtain information on breastfeeding and other risk factors. Mean duration of breastfeeding per child was significantly associated with a reduced risk of breast cancer for women who breastfed for > 24 months per child. The OR was 0.46 (95% CI, 0.28-0.76) when compared those who breastfed for < 6 months. The test for trend was significant (p = 0.01). A significantly reduced risk of breast cancer was found for those whose lifetime duration of breastfeeding was 73-108 months (OR = 0.65, 95% CI, 0.36- 1.18) and for those who breastfed for > or = 109 months (OR = 0.42, 95% CI, 0.20-0.84). Stratification by menopausal status showed a reduced risk of breast cancer associated with a longer duration of breastfeeding for both pre- and postmenopausal women. The risk reduction was more consistent for lifetime duration of breastfeeding, the test for trend being significant for both pre- (p = 0.03) and postmenopausal (p = 0.01) women. These results support an inverse association between breastfeeding and breast cancer risk.

Background. Radiation-induced sarcomas are well-known potential late sequelae of radiation therapy. They are of rare occurrence in jaw bones and are even rarer in the maxilla. Case report. We report a case of radiation-induced osteosarcoma involving the maxilla in a patient treated with radiotherapy for nasopharyngeal carcinoma 14 years ago. Despite neoadjuvant chemotherapy, surgical treatment could not be performed, and the patient received palliative chemotherapy. Conclusions. Radiation-induced osteosarcomas are aggressive and often elude early detection and timely intervention, rapidly leading to early demise of afflicted patients. Long-term patient follow-up and a high index of suspicion are crucial for timely intervention.

The SLN identification and false-negative rates after NAC for IBC were unacceptably high and based on the current findings, SLNB without systematic axillary lymph node dissection is unsuitable in this patient population.

Résumé Ce travail a pour objectif de préciser les aspects anatomo-cliniques et les paramètres pronostiques des cancers du sein dans la région du centre tunisien. Cette étude rétrospective porte sur 729 patientes atteintes de cancers mammaires prouvés à l’histologie et/ou à la cytologie, diagnostiqués et traités entre janvier 1990 et juin 1998 au CHU F Hached de Sousse (Tunisie). L’âge moyen était de 50 ans (extrêmes 22-91 ans). La taille clinique moyenne au diagnostic était de 49,1 mm ; 90 % étaient des carcinomes canalaires infiltrants avec un grade histopronostique SBR souvent élevé (grade II et III : 82,6 %). Le taux de survie globale de l’ensemble des patientes était de 50,5 % à 5 ans et de 50 % à 7 ans. En étude monofactorielle, les paramètres pronostiques étaient la taille tumorale, le statut ganglionnaire clinique, les métastases au diagnostic, le nombre de ganglions envahis, les ruptures capsulaires et les embols lymphatiques, le grade SBR et le délai de consultation. L’analyse multifactorielle (modèle de Cox) a isolé 2 paramètres pronostiques : la taille tumorale initiale (p = 0,001) et les métastases au diagnostic (p = 0,01). Le pronostic du cancer du sein demeure réservé en Tunisie du fait, notamment, du diagnostic tardif.

In this study, we investigated the associations of polymorphisms in glutathione-S-transferases (GSTs) genes that are GSTM1, GSTT1, and GSTP1, with sporadic colorectal cancer (CRC). Hundred and fifty patients with CRC and 128 healthy controls were genotyped. DNA was isolated from blood samples. Polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism-based methods and polymerase chain reaction multiplex. Logistic regression analyses showed significant risk for CRC associated with GSTP1 homozygotes for Val-105 (OR 4.82; 95 % CI 1.97-11.80) or for individuals who possessed at least one Val-105 allele (OR 2.54; 95 % CI 1.751-3.703). There were no statistically significant differences in the frequency of GSTM1- and GSTT1-null genotypes (p > 0.05). The GSTM1-null was found in 70.47 % of all cases and 70.07 % of controls (OR 0.61; 95 % CI 0.33-1.12). The GSTT1-null genotype was found in 38.77 % of cases and 49.22 % of controls (OR 1.53; 95 % CI 0.94-2.47). No effect of any genotype for GSTM1 and GSTT1 on CRC was detected. But then an association between the polymorphism of the GSTP1 and the CRC susceptibility was detected.

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