The [3+2] cycloaddition of CF3CHN2, generated in situ, with electron‐deficient alkenes/alkynes affords CF3‐substituted pyrazolines/pyrazoles in quantitative yields. The one‐pot three‐component reaction between CF3CH2NH2·HCl, NaNO2, and the substrate proceeds at room temperature in dichloromethane/water.
Five CF3‐substituted 3‐azabicyclo[n.1.0]alkanes were synthesized by CuCl‐mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides with CF3CHN2.
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