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Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of increasing importance in the treatment of HIV-1 infected persons. In this review the focus is on the syntheses of the approved NNRTI drugs efavirenz, delavirdine, nevirapine, and their analogues. This review also deals with the syntheses of the most promising NNRTI candidates in clinical testing and with the syntheses of subclasses of NNRTIs with known crystal structures when complexed with the reverse transcriptase enzyme.

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