In the well-vascularized dental pulp vascular endothelial growth factor A (VEGF-A) is expressed. Vascular endothelial growth factor A is a member of the VEGF family, which includes VEGFs-B, -C, and -D. The latter three have not been investigated in the pulp. Vascular endothelial growth factors C and D are the only ligands for vascular endothelial growth factor receptor (VEGFR)-3, which is usually expressed in lymphatic endothelium. They can also activate VEGFR-2, the main angiogenic receptor. We aimed to study VEGFs signalling in human dental pulp at the gene level and to identify the cellular source for protein expression using immunolabelling. All VEGFs (-A, -B, -C, and -D) were expressed in the pulp and may exert both autocrine and paracrine effects in blood vessels and immune cells found to be equipped with VEGFRs-2 and -3. Lymphatic vessel endothelial hyaluronan receptor-positive macrophages, known to be involved in angiogenesis, were found in the pulp, whereas lymphatic vessels were not detected. Twenty-six of 84 VEGF signalling genes, including VEGFR-3, were expressed at a significantly higher level in the pulp than in the control periodontal ligament. In conclusion, the normal human pulp represents a tissue with relatively high VEGF signalling involving both immune responses and vascular activity.
A
bstract
Aim
This case report illustrates the multidisciplinary treatment of a 12-year-old boy with esthetic challenges and endodontic problems in his maxillary incisors after severe dental injury at the age of 2½ years.
Background
The close anatomic relationship of the primary tooth to the permanent tooth germ explains why traumatic dental injuries in primary dentition may affect the development of permanent teeth especially in the maxillary anterior region. Developmental defects of enamel (DDE) as well as crown/root dilacerations are often seen after displacement injuries such as intrusion or avulsion occurring at lower age.
Case description
A 12-year-old boy with severe discoloration and enamel hypoplasia of his maxillary incisors was treated with composite restorations. History of avulsion injury of teeth 51 and 61 at the age of 2½ years explained the DDE, the severe dilaceration, and delayed tooth eruption of tooth 21. Use of cone-beam computed tomography (CBCT) was decisive in diagnosis and treatment planning of esthetic concerns and endodontic complications.
Conclusion
Trauma to primary teeth taking place at early childhood may have severe consequences on permanent successors.
Clinical significance
Severe morphological variations in permanent incisors caused by dental injuries in the predecessor teeth require monitoring and multidisciplinary approach. Advanced three-dimensional radiographic imaging is useful in identification and treatment planning of such cases.
How to cite this article
Bletsa A, Bessonova MV, Iden O. Using Cone-beam CT in Diagnosis and Management of Severe Dilaceration Following Trauma in Primary Teeth: A Case Report. Int J Clin Pediatr Dent 2020;13(S-1):S110–S114.
Hovedbudskap
Tannleger i Den offentlige tannhelsetjenesten i to Vestlandsfylker følger stort sett de gjeldende retningslinjer for endodontisk behandling.
Yngre tannleger utfører oftere trinnvis ekskavering og behandler mer dyp karies i melketenner enn de mer erfarne tannlegene.
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