From the plant Schefflera arboricola, which has been reported to cause allergic contact dermatitis, we have isolated and determined the elicitor of allergic contact dermatitis as falcarinol, heptadeca-1,9(Z)-diene-4,6-diyne-3-ol. Three polyacetylenes closely related to falcarinol, namely falcarindiol, falcarinone and dehydrofalcarinone were tested simultaneously. Falcarinol, but not falcarindiol, falcarinone and dehydrofalcarinone, elicited allergic contact dermatitis in a 38-year-old female plant-nursery worker.
From 1973 to 1977 a total of 3,225 patients were patch tested at the Department of Dermatology, Odense University Hospital, Denmark; 1,038 patients reacted to one or more allergens. The data on frequency of the most common allergens are presented. The most common allergens observed were nickel, dichromate, balsam of Peru, wood tar, carba mix and wool alcohols.
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