In the present study, we performed sciatic nerve compression for 30, 45, and 60 minutes by the Yasargil aneurysm clip and observed recovery on postoperative days 14, 28, and 42. We observed that as compress time increases, functional recovery and morphological regeneration of crushed sciatic nerve needs longer time. Additionally, we showed which cells are durable in nerve regeneration after crush injury. Nerve regeneration or recovery depends on trauma durations in which a longer recovery time is needed after longtime pressure. Although Schwann cells are found to be resistant and this might be for the cleanup of debris and remyelinization at mild injury, macrophage infiltration is necessary for the cleanup of damaged fragments of cells and fibers. The result indicates that a strong relationship exists between nerve damage and subsequent recovery. This phenomenon may depend on crush severity that is associated with mechanic pressure and inadequate logistic supports such as malnutrition and hypoxia. Additionally, we found that the Yasargil aneurysm clip is an appropriate device to perform a standard experimental severe crush injury model.
A great number of devices were used to make a peripheral nerve injury. In the scientific literature, experimental crush injuries have been usually created using forceps or hemostatic forceps, neither of which allows quantitative or standard application of compression. Therefore, we used a Yasargil-Phynox aneurysm clip to make a reliable and standardized peripheral nerve injury. The advantages and disadvantages of this clip were discussed. In particular, we think that standardization of the compression is necessary to compare interlaboratory results.
Although various administration routes of FK506 have been published, intrathecal administration of FK506 has not previously been reported in the literature. A daily dose of 0.05 mg/kg of FK506 was given (a small dose compared with those reported in the available literature). The authors used this small dose to obtain lower immunosuppression and neurotoxicity, and a higher axonal regeneration rate. A total number of 40 female Wistar rats were used and randomly divided into four groups: control, sham, FK506-treated, and vehicle-treated. Sciatic nerve regeneration was evaluated by walking track analysis, an electrostimulation test, and light microscopic evaluation. There was a statistically significant difference ( P < 0.05) between FK506-treated and vehicle-treated groups at the end of 6 weeks according to both the walking track analysis and the electrostimulation test. Comparing the stimulus thresholds of the sham and FK506-treated group, no significant difference ( P > 0.05) was observed. Evaluation of the data revealed that FK506 had a beneficial effect on sciatic nerve regeneration.
Objective: The aim of this study was to investigate whether there are glenohumeral morphological differences between normal population, glenohumeral instability, and rotator cuff pathology. Method: In this study, shoulder magnetic resonance (MR) images of 150 patients were evaluated. Patients included in the study were studied in three groups of 50 individuals: patients with anterior shoulder instability in group 1, patients with rotator cuff tear in group 2, and control subjects without shoulder pathology in group 3. Results: There were statistically significant differences between groups in evaluations for glenoid version, glenoid coronal height, glenoid coronal diameter, humeral axial and coronal diameters, and coracohumeral interval distances. Significant differences were observed between groups 2 and 3 in glenoid axial diameter, glenoid coronal height, glenoid depth, humeral coronal diameter, and coracohumeral distances.
Conclusion:The results obtained in this study suggest that glenoid version, glenoid coronal height and diameter, humeral diameter, and coracohumeral interval parameters in glenohumeral morphology-related parameters in patients with anterior instability are different from those of normal population and patients with rotator cuff pathology. In cases where there is a clinically difficult diagnosis, these radiological measurements will be helpful to clinicians in diagnosis and treatment planning, especially in cases of treatment-resistant cases.
Peripheral-nerve trauma has been a challenge to surgeons, with significant advances in the surgery of repair. Immobilization of the injured limb after repair has been the traditional method of treatment. Although peripheral-nerve regeneration has been studied extensively, the correlation between functional recovery and the immobilization period has not been well-documented. In the present study, the authors studied the effects of immobilization on axonal regeneration after sciatic crush injury. They found a detrimental effect of immobilization on the functional recovery.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.