Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease of the lung with a high mortality and morbidity rate. Some of the inflammatory markers such as C-reactive protein (CRP), leukocyte count are associated with COPD. In this study, we aimed to evaluate the role of neutrophil-to-lymphocyte ratio (NLR) in COPD patients comparing with the other well-known inflammatory markers. We retrospectively enrolled the laboratory results of 269 COPD patients of which 178 patients at stable period and 91 patients during acute exacerbation and 50 sex- and age- matched healthy controls. We found that NLR values of the stable COPD patients were significantly higher than those of the controls (P < 0.001). During acute exacerbation of the disease there was a further increase compared to stable period (P < 0.001). NLR values were also positively correlated with serum CRP levels and red cell distribution width (RDW) and negatively correlated with mean platelet volume (MPV) in both COPD groups. In conclusion, NLR could be considered as a new inflammatory marker for assessment of inflammation in COPD patients with its quick, cheap, easily measurable property with routine complete blood count analysis.
This study indicates that pulmonary rehabilitation can prevent loss of muscle strength in ICU. Nevertheless, we consider that further studies with larger populations are needed to examine the impact of NMES and/or active and passive muscle training in bedridden ICU patients who are mechanically ventilated.
The BQ is a poor predictor of obstructive sleep apnea (OSA) in subjects admitted to our sleep clinic. BQ and ESS together may be used to detect patients with low risk for OSA.
Instability in circulation, hypoperfusion, hypoxia, and ischemia in pulmonary thromboembolism (PTE) may occur as a result of failure in pulmonary circulation. All these conditions cause inflammation and oxidative stress. We aimed to investigate inflammatory markers, asymmetric dimethylarginine (ADMA) levels, and the oxidant-antioxidant balance in patients with PTE. This study was conducted as a prospective case-control study. Thirty-eight patients with PTE enrolled to the study. Age- and gender-matched 38 healthy subjects without risk factors for pulmonary embolism were selected as control group. Venous blood samples were obtained from the PTE patients during the initial diagnosis and at the first month of treatment and from the control subjects. Interleukine-6 (IL-6), tumor necrosis factor alpha (TNF-α), total antioxidant status (TAS), total oxidant status (TOS), and ADMA levels were measured for all the samples. The results of patients and healthy subjects were compared. The mean age of the control group was 51.81 ± 15.18 years, and the mean age of the patients was 52.90 ± 18.22 years (p = 0.770). Deep venous thrombosis was present in 68 % of the patients. While we found significant differences between the patient and control groups in terms of IL-6, TAS, TNF-α, ADMA and oxidative stress index (OSI) values (p = 0.001, p = 0.011, p = 0.038, p = 0.028, and p = 0.024, respectively), the TOS value was not different between the groups (p = 0.080). The ADMA, TNF-α, TAS, TOS, and OSI values of the patients during the initial diagnosis and at the first month of treatment were not different (p > 0.05). The results of this study indicate an increased inflammation, endothelial damage, and oxidative stress in PTE. No difference at the first month of therapy suggests ongoing processes. We consider that these markers may be useful in the diagnosis and follow up of PTE.
IntroductionChronic obstructive pulmonary disease (COPD), one of the most common chronic diseases, is a major cause of morbidity. Oxidative stress is a situation of imbalance between free radicals and antioxidants in favor of the oxidants (1). Today, habitual smoking is the most significant threat to the world's population (2). The development of COPD is mainly associated with tobacco or biomass smoke-induced oxidative stress. Smokers are exposed to thousands of reactive chemicals and trillions of radicals and particles with every cigarette; thus, the molecular reactive oxygen, activity of radicals, and nitrogen species can, over time, lead to a number of detrimental changes in the lungs (3). Oxidative stress is thought to play a central role in the pathogenesis of COPD.Maximal aerobic capacity (VO 2 max) is considered the gold standard for evaluating cardiorespiratory fitness (physical functional capacity) (4). Daily physical activity is the actual level of physical performance that one adopts in daily living. It is not synonymous with physical functional capacity, which can be defined as the maximal performance potential of an individual (5). Aerobic exercise limitation is a common and disturbing manifestation of COPD and is often caused by multiple interrelated physiologic and anatomic disturbances (6). Nevertheless, a hypothesis was proposed that individuals with higher current aerobic function will have greater antioxidant and metabolic capacities to deal with the stresses associated with life, including environmental stresses such as chronic cigarette smoke exposure (3).Patients with COPD show high prevalences of cardiovascular diseases and metabolic syndrome (7,8). Obesity and COPD are common and disabling chronic health conditions. A relationship between obesity and COPD is increasingly recognized, although the nature of this association remains unknown (9). Uygur et al. also found that body fat percentage and total body fat were negatively correlated at a strong level with aerobic capacity Background/aim: To investigate total oxidant and antioxidant status, maximal aerobic capacity, daily physical activity, pulmonary functions, and body composition changes, as well as the associations among these parameters, in patients with mild to moderate chronic obstructive pulmonary disease (COPD) versus healthy controls. Materials and methods:The study included 30 male patients newly diagnosed with COPD and 30 body mass index-matched, nonsmoker male controls. Maximal aerobic capacity, daily physical activity, total oxidant and antioxidant status, pulmonary function tests, body composition, and anthropometric parameters were measured.Results: Maximal aerobic capacity and total antioxidant values were lower in patients with COPD compared to the controls. The total oxidant value, body fat percentage, and waist/hip ratio were higher in patients with COPD than in the healthy controls. There was a moderately negative correlation between the total oxidant value and the maximal aerobic capacity, while there was a moderatel...
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