Background: Lymph node (LN) metastasis of gastrointestinal stromal tumors (GIST) is unusual. Unlike gastric adenocarcinomas, routine lymphadenectomy is not recommended unless there is no suspicion for LN metastasis. Herein, we report a case of GIST of the stomach with LN metastasis treated with distal gastrectomy with perigastric LN dissection followed by adjuvant imatinib therapy.
CD10-common acute lymphoblastic leukemia antigen is a membrane-bound zinc metalloproteinase that is expressed by different hematopoietic cell types at unique stages of lymphoid and myeloid differentiation. It was reported to be expressed in various nonlymphoid cells and tissue, as well as in various types of neoplasms. Recently, it has been found to be useful in the differential diagnosis of benign and malignant follicular-patterned lesions of the thyroid. In the present study, we evaluated the staining pattern of CD10 in various thyroid lesions, including 14 benign and 61 malignant cases, as well as in adjacent thyroid tissue. CD10 was negative in normal thyroid tissue, adenomatous nodules, minimally invasive follicular carcinoma, and well-differentiated carcinoma. It was expressed in nine of 14 (64.2%) conventional papillary carcinomas, four of 24 (16.6%) follicular variant of papillary carcinomas, three of six (50%) papillary microcarcinomas, one of nine (11.1%) widely invasive follicular carcinomas, and three of ten (30%) follicular adenomas. In contrast to results of previous studies, CD10 is not useful in the classification of thyroid follicular lesions as benign or malignant, but it shows strong positivity in conventional papillary carcinoma.
A 31-year-old man presented with a twenty-year history of a slowly growing nodule on his scalp in the postauricular area. The lesion was excised and with the clinical and histological findings, it was diagnosed as a pilonidal sinus. The purpose of this review is to report the unusual occurrence of a pilonidal sinus on the scalp and review the literature regarding especially this location.
Introduction. Carcinoid tumors are low-grade tumors originating from endoderm and mostly involving the gastrointestinal system. However; they may be seen in any site within the gastrointestinal system. Case Presentation. A 69-year-old female patient. The results of blood tests were observed to be consistent with obstructive jaundice. A mass appearance was not encountered on tomographic examination. Papilla that was tumor-like macroscopically was seen in the second part of the duodenum in diagnostic endoscopy. Pylorus—preserving pancreaticoduodenectomy surgical procedure was applied. On pathological examination of the mass, a tumoral mass was detected in ampulla vateri localization, 1.5 × 1 × 0.8 cm in size, which, in immunohistochemical staining, was evaluated as a neuroendocrine tumor. Also, Metastasis was observed. Conclusion. The rarest type of carcinoid tumor is ampullary located carcinoid tumor, and tumor size is not a reliable indicator for tumor aggressivity in ampullary carcinoid tumors.
intact. Histologically, the tumor was well-circumscribed and highly vascular, and tumor nests were separated by fascicles of smooth muscle (Figure A,b). The tumor cells were uniform, small, round to oval central nuclei containing stippled chromatin (Figure C). nucleoli were not prominent. The cytoplasms were eosinophilic or clear. One mitosis was found in 50 HPF (high-power fields). immunohistochemically, the tumor cells stained diffusely positive for smooth muscle actin (sMA)(neomarkers, CA, usA) (Figure 2A) and vimentin (neomarkers, CA, usA) (Figure 2b), focal positive for CD34 (neomarkers, CA, usA) (Figure 2C), and focal and weak positive for synaptophysin (Dako, Denmark) (Figure 2D). All other markers, including cytokeratins (AE/AE3, neomarkers, CA, usA), CD7 (Dako, Denmark), chromogranin A (neomarkers, CA, usA), s-00 (Dako, Denmark), and desmin (Dako, Denmark) were negative. DISCUSSION Glomus tumor is derived from the specialized cells of the glomus apparatus (2). Vascular tumors of the gastrointestinal
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