The study aimed to compare the effectiveness of various pharmacotherapy regimens for infertility of tubo-peritoneal genesis. Under constant supervision were 96 patients referred to the hospital for diagnostic laparoscopy for infertility of tubo-peritoneal genesis, divided equally into 4 groups depending on the pharmacological treatment methods: the 1st group received basic pharmacotherapy (BPT) after endoscopic surgery (antibacterial, antifungal, vitamin therapy). Patients of groups 2-4, in addition to BPT, received Hepon, Cycloferon or Lavomax, respectively. The control group consisted of 38 gynecologically healthy women. Laboratory examination was performed within 24 hours after the operation and on the 30th day after BPT. Vaginocervical lavage and plasma were assayed for the activity of lipid peroxidation processes, the state of the antioxidant system, the level of stable nitric oxide metabolites, neopterin, C-reactive protein, cytokines (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA, sIgA), components of the complement system (C3, C4, C5, C5А), phagocytic and oxygen-dependent activity of polymorphonuclear leukocytes. It was established that the use of immunomodulatory and antiviral activity medication with BPT according to the degree of increasing efficiency in the correction of immunometabolic laboratory parameters at the systemic and local level in infertility of tuboperitoneal genesis is as the following sequence: basic pharmacotherapy < basic pharmacotherapy + Hepon < basic pharmacotherapy + Cycloferon < basic pharmacotherapy + Lavomax.
Garcinia kola has been confirmed for spermatogenic and tissue enhancing effect of testis in male wistar rats. This study was carried out to investigate the histological effect of ethanolic extract of Garcinia kola on Lead II oxide induced testicular damage. Thirty five (35) adult male wistar rats were randomly selected into seven (7) groups n=5. Group A received 0.5 ml saline solution, Group B received 100 mg/kg of Garcinia kola extract only, Group C received 5 mg/kg of Lead II oxide only, Group D 1 received 100 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group D 2 received 200 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group E received 500 mg/kg of vitamin E only and Group F received 500 mg/kg of vitamin E and 5 mg/kg Lead II oxide. Administration was done orogastrically daily for 2 weeks, animals were sacrificed 24 hours after the last administration by cervical dislocation and the testes excised following abdominal incision for histological observation using H/E stain. Slight degeneration of the germinal epithelium of the seminiferous tubule and abnormal widening of the interstitial space involving loss of Leydig were observed following the administration of Lead II oxide. However, Improvements in the testicular architecture were noticed in the rats treated with the Garcinia kola and the Vitamin E respectively thus histological integrity maintained.
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