Depression, anxiety and stress are recognised as global public health problems especially in developing countries. Early detection of these disorders is essential to provide psychological interventions for individuals experiencing these negative emotional conditions. This study determined the Nigerian psychometric properties for the 21-item version of the depression, anxiety and stress scale among a sample of medical students. Two hundred and forty medical students from the Lagos State University College of Medicine, Lagos, Nigeria completed the depression anxiety and stress scale, state trait anxiety inventory and self-rating depression scale. The reliability, discriminative, concurrent and convergent properties were determined. The reliability of DASS-21 showed that it has excellent Cronbach's alpha values of 0.81, 0.89 and 0.78 for the subscales of depressive, anxiety and stress respectively. It was found to have excellent internal consistency, discriminative, concurrent and convergent validities. The depression and anxiety subscales of DASS-21 had good correlations with self-rating depression scale and state trait anxiety inventory. The DASS-21 was found to have

Background: The manifestations of subjective traumatic distress among emergency nurses in Nigeria have not been extensively studied. Objective: To determine the prevalence and correlates of subjective traumatic distress among emergency department nurses in Lagos, Nigeria. Methods: One hundred nurses working at the Emergency Department of the Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria, were surveyed for the impact of subjective traumatic distress using the Revised Impact of Event Scale. The sociodemographic characteristics and some work-related factors were also determined. Results: Of the 100 participants, 60 (60%) met the criteria for the impact of subjective traumatic distress. The overall mean score of the participants for the IESR was 27.9 ± 6.7 with a range of 0 to 66. The most frequent symptoms of subjective trauma distress sub-scale included avoidance symptoms, (mean: 12.2± 9.1; range 0-28) intrusion symptoms (mean: 7.3 ± 3.8; range 0-20) and hyperarousal symptoms (mean: 5.3 ± 1.6; range 0-17). Female participants had higher exposures in the sub-scales of the IESR scores. The associations between sociodemographic parameters such as age, gender and marital status and the subscales of the IESR were not significant. Conclusion: The study showed that more than half of the participants experienced subjective psychological traumatic distress. There is a need for hospital managers to provide psychological interventions regularly for emergency department nurses to prevent occurrence of psychopathologies such as burnout and posttraumatic stress disorders.

Background Although the phenotype of polycystic ovary syndrome (PCOS) is heterogeneous, there is paucity of data on the prevalence and phenotype of PCOS in sub-Saharan Africa. Methods We studied 75 consecutive consenting women, aged 18-45 years, who presented with features suggestive of PCOS. A standardized proforma was used to obtain relevant information. Anthropometric measurements were determined, and terminal hair growth was assessed using the modified Ferriman-Gallwey (mF-G) method. All subjects underwent an oral glucose tolerance test (OGTT) and pelvic ultrasonography on day 2-7 of the menstrual cycle. An mF-G score of ≥ 6 was regarded as evidence of clinical hyperandrogenism (HA). Menstrual dysfunction (MD) was defined as menstrual cycle lengths >35 or <25 days. Polycystic Ovarian Morphology (PCOM) was defined as an antral follicle count (AFC) of ≥12 2-9 mm follicles and/or an ovarian volume ≥10 cm3, in at least one ovary. Results The mean (SD) age of the study population was 28.6 (5.8) years, and the mean (SD) body mass index (BMI) was 26.3 (5.6) kg/m2. Three (4.0%) participants were underweighted, 27 (36.0%) had normal BMI, 30 (40%) were overweight, and 15 (20.0%) were obese. The mean (SD) systolic and diastolic blood pressures were 107.4 (12.6) mmHg and 72.6 (8.2) mmHg, respectively. OGTT results indicated that the mean (SD) fasting blood glucose was 86.6 (10.6) mg/dl and the mean (SD) 2-hr. postprandial glucose was 109.8 (22.2) mg/dl. Two women had impaired glucose tolerance and one had type 2 diabetes mellitus. Of the 75 subjects recruited, 26 (34.7%) had HA, 54 (72.0%) had MD, and 63 (84.0%) had PCOM. Of all subjects, 20 (26.7%) had HA+MD+PCOM, consistent with PCOS Phenotype A; one (1.3%) had HA+MD only, consistent with Phenotype B; four (5.3%) had HA+PCOM only, consistent with Phenotype C; and 28 (37.3%) had MD+PCOM only, consistent with Phenotype D. In 22 (29.4%) no evidence of PCOS was found. Overall, our results indicate that of subjects evaluated clinically, 53 (70.6%) had PCOS. Conclusions Our preliminary results indicate that in a referral (clinical) population in Lagos, Nigeria, using only the clinical presentation without circulating androgen measures, PCOS was detected in two-thirds, with Phenotype D (aka, 'non-hyperandrogenic PCOS’) being the most common presentation (53%), followed by Phenotype A (aka 'classic or full PCOS’) observed in 38% of all women with PCOS seen. However, as 72% of all subjects had MD and 63% had PCOM, many more of these women could have been diagnosed with PCOS if the presence of hyperandrogenemia could have been demonstrated. Overall, these observations suggest that accurate measurement of circulating androgen, lacking in many parts of Sub-Sahara Africa, may be critical to accurately detecting PCOS in that region. Studies are ongoing. Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.

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