Abstract. The Owo River is an important surface water source in Lagos particularly to the western section. It is the source of direct water intake for water supply by Lagos State Water Corporation to Amuwo-Odofin, Ojo and parts of Badagry Local Government Areas. This paper examines the complex interactions and feedbacks between many variables and processes within that catchment and analyses the future ability of this semi-urban watershed in sustaining water supply in the face of cumulative environmental change. Stationarity analysis on rainfall, change detection analysis and morphometry analysis were combined to analyse the non-stationarity of Owo River catchment. On rainfall trend analysis, since the correlation coefficient (0.38) with test statistic of 2.17 did not satisfy the test condition we concluded that there is trend and that rainfall in the watershed is not stationary. The dominant land use impacting on the bio-geochemical fluxes is built up area (including structures and paved surfaces) which grew from about 142.92 km 2 (12.20 %) in 1984 to 367.22 km 2 (31.36 %) in 2013 recording gain of 224.3 km 2 at average growth rate of 7.73 km 2 per annum. Total length of streams within the catchment reduced from 622.24 km in 1964 to 556 km in 2010, while stream density reduced from 0.53 in 1964 to 0.47 in 2010 an indication of shrinking hydrological network. The observed trends in both natural and anthropogenic processes indicated non-stationarity of the hydrological fluxes within the Catchment and if this continues, the urban ecosystem services of water supply will be compromised.

Treatment options are limited for patients with anemia associated with lower-risk myelodysplastic syndromes (LR-MDS). The recent approval of luspatercept for the treatment of anemia associated with very low- to intermediate-risk MDS with ring sideroblasts (RS) or with myelodysplastic/myeloproliferative neoplasm with RS and thrombocytosis has provided adult patients and practitioners with a much-needed new therapeutic option. Luspatercept is a first-in-class erythroid maturation agent that exerts its effects on later stages of erythropoiesis. In the phase III MEDALIST trial of patients with LR-MDS with RS, luspatercept (starting dose 1 mg/kg) demonstrated substantial clinical benefit (38% of patients treated with luspatercept vs. 13% of those treated with placebo [p < .001] achieved transfusion independence for ≥ 8 weeks during the first 24 weeks of treatment) and a favorable safety profile. The most common adverse events (AEs), including fatigue, asthenia, dizziness, and diarrhea, were more frequent during the first 4 treatment cycles and subsequently declined. This review provides a comprehensive overview of luspatercept treatment administration, including the mechanism of action, efficacy and safety data, management of dosing, and AEs associated with luspatercept treatment of patients with LR-MDS.

Abstract. The study examines the interplay among water resources, hydropower generation and agricultural landuse at the Shiroro hydropower station and its environs, in north-central Nigeria. Non-parametric trend analysis, hydropower footprint estimation, reservoir performance analysis, change detection analysis, and inferential statistics were combined to study the water-energy and food security nexus. Results of Mann-Kendall test and Sen's slope estimator for the period 1960 to 2013 showed a declining rainfall trend at Jos, around River Kaduna headwaters at −2.6 mm yr −1 , while rainfall at Kaduna and Minna upstream and downstream of the reservoir respectively showed no trend. Estimates of hydropower footprint varied between 130.4 and 704.1 m 3 GJ −1 between 1995 and 2013. Power generation reliability and resilience of the reservoir was 31.6 and 38.5 % respectively with year 2011 being the most vulnerable and least satisfactory. In addition to poor reliability and resilience indices, other challenges militating against good performance of hydropower generation includes population growth and climate change issues as exemplified in the downward trend observed at the headwaters. Water inflow and power generation shows a weak positive relationship with correlation coefficient (r) of 0.48, indicating less than optimal power generation. Total area of land cultivated increased from 884.59 km 2 in 1986 prior to the commissioning of the hydropower station to 1730.83 km 2 in 2016 which signifies an increased contribution of the dam to ensuring food security. The reality of reducing upstream rainfall amount coupled with high water footprint of electricity from the reservoir, therefore requires that a long term roadmap to improve operational coordination and management have to be put in place.

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