Background: Carbonated drinks are widely consumed because of their taste and their ability to refresh and quench thirst. These carbonated drinks also exist in the form of diet drinks, for example Diet Coke® , Pepsi®, extra. Objectives: A comparative effect of the diet and regular soda carbonated drinks on the histology of the cerebellum of female albino Wistar rats was investigated. Methods: Fifteen adult female Wistar rats weighing between 180-200g were divided into 3 groups; designated as groups A, B and C, and each group consisted of five rats. Group A was the Control group and received distilled water, while groups B and C were the experimental groups. Group B was administered 50 ml of regular soda (RS), and group C was administered 50 ml of diet soda (DS) each per day for 21 days, and the rats were sacrificed on Day 22, and their cerebellums excised and preserved. Results: Histological result of the sections of the cerebellum showed shrunken and degenerated Purkinje cells with hypertrophied dendrites, especially in the DS group, which was less in the RS group compared to the control group. Conclusions: These results suggest that diet soda has adverse effect on the cerebellum of adult female albino Wistar rats.

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The effects of ethanol extract of Spondias mombin leaf on male rats' fertility were investigated. The extract was orally administered with 250 and 500mg/kg doses for 8 weeks. There was significant decrease in testicular and epididymal weight in the treated animals compared to the control. Histomorphology of the testis showed distortion in the arrangement of seminiferous tubules, loose germinal epithelium, low number of germ cells and Sertoli cells. Tubular sizes of epididymis were reduced with vacuolation and decreased sperm. The serum level of testosterone was significantly decreased (p<0.05) at 500mg/kg compared to control. We conclude that Spondias mombin leaf extract can suppress the process of spermatogenesis which can lead to infertility in laboratory animals.

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