Background: Breast cancer is one of the most important tumours affecting women in Nigeria and all over the world, with high morbidity and mortality if detection is delayed. Objectives: This study was carried out to review the histology of all breast biopsies sent to Histopathology Laboratory in UDUTH. Method: Using haematoxylin and eosin staining method, breast biopsies received from January 2002 to December 2011 were analyzed. Demographic data such as age, sex, site of the biopsy of all the patients were obtained through histology request card and biopsy registers. Result: A total of 788 breast samples were received during the period under review, 403 samples (51.1%) were benign lesions, 256 samples (32.5%) malignant lesions and 61 samples (7.7%) are inflammatory lesions. The age group with the highest occurrence of breast pathology is 20-29 years which are mostly benign lesions, with 50-59 years age group having the highest occurrence of malignant lesions. Conclusion: The study indicated that most breast lesions occurring in the first three decades of life are benign, while those in the elderly are mostly malignant. We recommend strong awareness among the populace to encourage early detection of these lesions.

Aim: Tamoxifen, once praised for its importance in preventing breast cancer recurrence, is now implicated in dangerous side-effects. The authors are not aware of studies on the effect of tamoxifen on the histomorphological and biochemical components of the liver of guinea pig, hence the present one. Methods: Thirty guinea pigs weighing between 650g and 700g were assigned randomly into 6 groups of five and were separately given 0.70 and 7.0mg/kg body weight (b.w) tamoxifen for 2 and 4 weeks. Liver function tests and conventional tissue processing haematoxylin and eosin staining method were used in the study. Results: The results showed a significant loss in body weight (p<0.05) of the guinea pigs administered with low and high doses of the tamoxifen for 4 weeks when compared with the controls. The mean serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin and conjugated bilirubin increased significantly than the controls in high dose groups exposed for 2 weeks and 4 weeks respectively (p<0.05). Similarly, histomorphological changes such as enlargement and sclerotic condition of central vein, enlargement and non-hexagonal radiating arrangement of sinusoids were observed in the liver of guinea pigs in the high dose tamoxifen

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