To identify the factors responsible for total parenteral nutrition (TPN) associated jaundice in the neonate, 77 newborns who had been started on TPN during the past 12 years had their charts reviewed. Forty-four (57%) of these infants developed jaundice during the 1st month of life. The incidence of jaundice was significantly higher in the presence of those diseases which were associated with impaired intestinal passage such as congenital duodenal atresia, jejunal atresia, etc, and those with an abnormal rotation of the gut such as diaphragmatic hernia, gastroschisis, etc. Thirty-two (42%) of these 77 infants had accompanying infectious signs, and 28 (88%) of those 32 infants with infectious signs developed jaundice. This incidence was significantly higher than that (36%) among those who had no infectious signs. Of the possible etiologic factors other than infection, neither the length of intrauterine life nor birth weight showed significant correlation with the incidence of jaundice. The incidence of jaundice tended to be higher in infants started on TPN at a younger age. There was no significant correlation between the incidence of jaundice and the duration of TPN or fasting period. Infants receiving 110 cal/kg/day or more during TPN developed jaundice significantly more frequently than those receiving fewer calories. No definite correlation was obtained between the incidence of jaundice and the amount of amino acids administered.
We studied the efficacy of mediumchain triglyceride (MCT) as an energy source in premature infants. Infants who were given 3 g/kg/day of MCT oil gained body weight better than the control group in spite of a smaller water intake. This is advantageous to premature infants who need water restriction due to patent ductus arteriosus (PDA), bronchopulmonary dysplasia (BPD), etc. We also proved that MCT oil is rapidly absorbed and digested, by means of the '3C-trioctanoin breath test. Jpn 1988;30: 564 -568)
(Acta Paediatr
We synthesized several polyether dicarboxylic acids with naphthalene and trimethylene groups as repeating units. The polyethers selectively formed complexes with lithium, an alkali metal. In contrast to the typical polyethers, their alkali metal complexes exhibited very low solubilities for water and hydrophobic organic solvents such as chloroform and toluene. Polyethers having seven naphthalene units formed a stable monolayer on an aqueous subphase, only when alkali metal hydroxides were added, but not acid.
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