ABSTRACT. Purpose: To compare the clinical and bacteriological effects of fucidic acid (FucithalmicA : 1.0%) and chloramphenicol (Minims A : 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin. Methods: A total of 456 newborns with gestational age Ͼ 32 weeks with acute conjunctivitis of suspected bacterial origin acquired within the first 28 days of life were included in the study. They were randomly assigned to a 7-day treatment with eye drops using either fucidic acid (1.0%) (Fucithalmic A ) applied twice per day, or chloramphenicol (0.5%) (Minims A Chloramphenicol) applied six times per day. The subjects were followed up with two visits (on days 1 and 8) and by telephone 2 weeks after the end of treatment. Results: Eighty-nine per cent of the neonates treated with FucithalmicA were cured, compared to 87.9% of those treated with Minims A Chloramphenicol (n.s). The drug was used as instructed in 90.7% of patients treated with Fucithalmic A and in 78.0% of those treated with Minims A Chloramphenicol (P ∞ 0.001). Conclusion: Treating neonatal conjunctivitis with fucidic acid is easier than with chloramphenicol and is equally effective.
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