Introduction:
Diabetes mellitus is a common disease worldwide. It is considered as the third leading cause of death, in the developed countries followed by heart diseases and cancer.
Aim:
The aim of this study was to assess the effectiveness of the aqueous fraction of R. mucronata and A. marina leaves grown in Saudi Arabia alone or in combination as antidiabetic agents and explore its effect on the antioxidants status.
Methods:
One hundred and twenty male Wistar albino rats were divided into 8 groups were utilized in this study. Streptozotocin (STZ) was utilized for induction of diabetes. The effects of daily oral administration of aqueous extract from the leaves of R. mucronata (400 mg/kg BW), A. marina (400 mg/kg BW) and the combination of both plant extracts for 6 weeks were evaluated on blood glucose, insulin, tissues’ antioxidants as well as pancreatic immunohistochemistry in normal, (STZ)-induced diabetic rats.
Results:
Oral administration of the plants extracts significantly reduced (p ≤ 0.001) serum glucose, insulin and improved the antioxidants status in the liver compared to the untreated rats. Immunohistochemically, the pancreas of diabetic rats treated with R. mucronata revealed a few islets β-cells (2-3%/ HPF) with positive caspase-3.
Conclusion:
The extract of R. mucronata exhibited a promising antidiabetic, antioxidant and tissue enhancing effects compared with A. marina alone or in combination.
Background: The conventional medications of diabetes mellitus have many side effects that bring to diabetic cases, so there is a need for introducing natural remedies with antidiabetic effect. The objectives of this study aimed to evaluate the hypoglycemic and antidiabetic effects of aqueous extracts of a mixture of R. mucronata and A. marina against experimentally streptozotocin (STZ) induced diabetic rats and to assess its efficacy in alleviating diabetes-induced impact on kidney function.Methods: Sixty rats distributed into four groups (n=15) were used in this study. They included the control, STZ-induced diabetic, STZ-induced diabetic treated with a mixture of Rhizophora mucronata and Avicennia marina extract and non-diabetic group received a mixture of Rhizophora mucronata and Avicennia marina extract. After 6 weeks of treatment, the biochemical and histological alterations were investigated in all rats.Results: Daily oral administration of a mixture of R. mucronata and A. marina leaves extract to STZ-induced diabetic significant (p≤0.001) increase serum insulin levels and reduced fasting blood glucose levels, serum BUN and uric acid compared to the untreated diabetic rats. This mixture also improved the renal degeneration and inflammation induced by diabetes and reduced the number of the apoptotic cell in both renal cortex and medulla.Conclusions: The mixture of R. mucronata and A. marina extract significantly improve the diabetes-associated biochemical and histopathological renal changes indicating its potential effect as a natural nephroprotective agent against diabetic-induced nephropathy.
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