This study was carried out to evaluate the biomarker response of male albino wistar rats (Rattus novergicus) to a daily dose of toothpaste. Twenty four wistar rats were divided randomly into two groups and housed in wooden cages. The first group which is the test group was administered in varying doses (250 ul, 270 ul, 300 ul) according to their body weight (0.00167 mg/g body weight) per week for three weeks while on the fourth week no treatment was administered. This was done to observe the rate of recuperation from the effects of treatment. The second group which was the control group were given distilled water of equal measurement with the treatment given to the test rats. Selected biochemical and hematologic parameters were used to evaluate the effect of toothpaste. Parameters used for liver functions were; alkaline aminotransferase (ALT), aspartate
The acute haematological response of a brackish water cichlid fish Sarotherodon melanotheron exposed to crude oil was evaluated. They were exposed for 96 h to crude oil concentrations of 0, 50, 125, 250, 375, and 500 mg/L of water obtained from the fish source. Haematological analyses were carried out at 12, 24, 48, 72, and 96 h, respectively. Haematological analysis revealed that the red blood cells (RBC), haemoglobin (Hb), packed cell volume (PCV), thrombocytes, and lymphocytes of the control group were significantly higher (P≤ 0.05) than the crude oil treated groups while the white blood cells (WBC), neutrophils, leucocrit (Lct) and monocytes of the crude oil treated groups were significantly higher than the control group, indicating an immune response to the toxicant. These parameters can be standardised and used as biomarkers in biomonitoring programs.
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