Intraperitoneally injected afobazole and its major metabolites are intensively distributed in highly vascularized tissues of rats, including the liver, spleen, and kidneys; the content of these compounds in moderately and poorly vascularized tissues (muscles and mesentery) is much lower. Afobazole and its metabolites possess intermediate ability to penetrate into the brain.
A highly sensitive and reproducible method for assay of fluvoxamine in biological samples using HPLC combined with various detection methods (spectrophotometry and tandem mass spectrometry) was developed. These methods were completely interchangeable and correlation analysis demonstrated high consistency in the results obtained by different detection methods: the Pearson correlation coefficient was 0.982 (p < 0.0001) and the slope of the regression line was close to unity. The methods were suitable for routine therapeutic monitoring of fluvoxamine in patients' serum.
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