Cally Roper and colleagues analyze the distribution of sulfadoxine resistance mutations and flanking microsatellite loci to trace the emergence and dispersal of drug-resistant Plasmodium falciparum malaria in Africa.

At recognition of treatment failure, patients on tenofovir-based first-line regimens had fewer NRTI drug-resistant mutations and more active NRTI drugs available for second-line regimens. These findings can inform strategies for ART regimen sequencing to optimize long-term HIV treatment outcomes in low-resource settings.

Easy access to antiretroviral medications and a well-targeted education and awareness campaign will help reduce the incidence and prevalence of the disease. The inability to perform histologic examinations on all suspected cases calls for a well-designed prospective study to determine the actual prevalence of Kaposi's sarcoma in HIV-seropositive patients in Nigeria.

SUMMARY Between 1977 and 1981, 3089 patients attended the sexually transmitted diseases (STD) clinic in Zaria, northern Nigeria. The male-to-female ratio of attenders was 6:1. Postpubertal gonorrhoea accounted for 28-1lo of cases, non-specific genital infections for 22 4%, and syphilis for 1 20o. Illiteracy, polygamy, the purdah system, widespread prostitution, and inadequate facilities are factors aiding the spread of these diseases in northern Nigeria.

No abstract