These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.
Abstract. An appropriately protected 3'-phosphoramidite and 5'-phosphate derivative of the modified 2'-deoxyuridine were obtained by P-glycosylation of a properly protected 5-hydroxymethyl-2'-dcoxyuridine, and subsequent elaboration of the resulting intermediates using standard protocols dcvised in nucleic acids chemistry.
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