New 5-Substituted Thiazolo[3,2-b][1,2,4]triazol-6-ones: Synthesis and Anti--cancer Evaluation. -The approach to the thiazolotriazolone system relies on [2 + 3]cyclocondensation of triazolethiol with the dielectrophilic synthon . Most of the target heterocycles display antitumor activity on renal cancer, leukemia, colon cancer, breast cancer, and melanoma cell lines. Compound (VIe) is highly active on all cell lines, especially on leukemia. -(LESYK*, R.; VLADZIMIRSKA, O.; HOLOTA, S.; ZAPRUTKO, L.; GZELLA, A.; Eur. J. Med. Chem. 42 (2007) 5, 641-648; Dep. Pharm., Org. Bioorg. Chem., L'viv State Med. Univ., L'viv 290010, Ukraine; Eng.) -H. Hoennerscheid 40-133 C 2+ 2
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