Objective. The aim of the study was to investigate the tuberculocidal efficacy of disinfectants according to the manufacturers instructions and the results of experimental studies using a test strain of Mycobacterium terrae.
Materials and methods. The instructions for 150 disinfectants (DS) were studied. An experimental evaluation of the tuberculocidal efficacy of 6 DS was carried out using the reference strain M. terrae.
Results. A study of the documentation for the DS showed that from the number of DS produced before 2010, only 38.2 % of the drugs were recertified after 2010. Of these, only in 50.0 % of cases it was noted in the instructions that the recertification was carried out using the test microorganism M. terrae. From the number of DS produced after 2010, only 49.2 % of the drugs were certified using the M. terrae test strain. According to the results of laboratory assessment of DS, it was shown that drugs that did not pass re-certification using M. terrae have low tuberculocidal efficacy.
Conclusions. It has been established that many manufacturers of DS during certification and recertification of drugs do not test the modes of their tuberculocidal efficacy on the regulated microorganism M. terrae. In the course of laboratory assessment of the tuberculocidal effect of DS, it was confirmed that the least effective drug was the one that did not pass re-certification using M. terrae.
Objective. Assessment of tuberculosis (TB) infection conditions for HIV-infected people.Materials and methods. Еpidemiological survey of 38 epidemic foci of HIV-associated tuberculosis, 28 foci of tuberculosis without HIV infection and 20 foci in which the diagnosis of tuberculosis wasn`t confirmed (control-group) were conducted.Results and its discussion. As it turns out that in the most cases of the development of HIV-associated TB, the primary diagnosis of HIV infection preceded the primary diagnosis of tuberculosis. According to the results of the case-control analytical epidemiological study, such risk factors of HIV-infected tuberculosis as lack of family, higher education and regular job, the fact of deprivation of liberty and drug users (as a reflection of the low social status of patients), as well as contact with tuberculosis patient were identified. Risk factors for mycobacteria infection in people without HIV infection were only the lack of family and contact with tuberculosis patients.
The attendance of patients with HIV infection, combined with tuberculosis, of different medical organizations was studied before and after limiting service of patients with co-infection in the AIDS center polyclinic. 163 flushes from the hospital environment of the AIDS centre polyclinic were studied by polymerase chain reaction for the presence of tuberculosis mycobacteria DNA. It was established that a decrease in the number of visits to a specialized polyclinic by the patients with HIV infection combined with tuberculosis was accompanied by a decrease in the degree of hospital facility environment contamination by tuberculosis mycobacteria.
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