Gene network modeling is one of the widely used approaches in systems biology. It allows for the study of complex genetic systems function, including so-called mosaic gene networks, which consist of functionally interacting subnetworks. We conducted a study of a mosaic gene networks modeling method based on integration of models of gene subnetworks by linear control functionals. An automatic modeling of 10,000 synthetic mosaic gene regulatory networks was carried out using computer experiments on gene knockdowns/knockouts. Structural analysis of graphs of generated mosaic gene regulatory networks has revealed that the most important factor for building accurate integrated mathematical models, among those analyzed in the study, is data on expression of genes corresponding to the vertices with high properties of centrality.
This article is dedicated to the study of the issue of ensuring the accuracy of environmental information disclosure and its informational and constitutional framework. Compliance with the obligatory transparency of environmental information, as well as its accuracy, the need for and reality of observance of informational and constitutional foundations for enforcement of the rights of citizens is the subject of heated discussions. The article makes an emphasis on the nonexistence of a definition for the term “accuracy of information” in the current Russian legislation. Due to the tightening of responsibility for the dissemination of fake information on the Internet, the problem of the definition of “the accuracy of environmental information” takes on special significance. The author calls attention to the facts of untimely disclosure of information about a number of environmental disasters and to the need for improvement of information and legal mechanisms.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.