Annotation. Endurance – one of the most important sports components, which allows you to overcome the workload for a given time without significant losses in strength and speed. It is most manifested in such sports as swimming, skiing, marathon, cycling, gymnastics. Since the endurance development is mostly influenced not only by epigenomic factors, but also by the genotype of the athlete, so the purpose of this review article is to study the effects of ACTN3 and ACE genes on this physical component. In order to do so, we used basic databases to process information that is known to date on the effects of these genes and their variations. The search was conducted up to and including January 2022 in accordance with PRISMA recommendations. Genes under our study affects endurance in different ways, for example, ACTN3 R577X polymorphism increases the number of slow muscle fibers, and the presence of wild allele “I” of the ACE gene slows down the bradykinin decomposition which mitigates the workload impact on the cardiovascular system, thereby facilitating its adaptation, although there is evidence of an increased risk of injury. The purpose of the review results is to help each athlete in selection of training tactics, which could help him in sports achievements.

Annotation. The impact of genetics on physiology and sports performance is one of the most controversial areas of sports medicine. Studies have shown that in addition to wild-type genes, almost 200 gene polymorphisms affect athletic performance, and more than 20 polymorphisms can determine the status of elite athletes. Sports results are manifested to a greater extent not only due to environmental factors, but also due to the athlete's own genotype, so the purpose of our review article is to study the effects of the PPARGC1A gene and its rs8192678 polymorphism on sports characteristics. For this purpose, we analyzed and processed the information known to date about a specific gene and the effects of its polymorphism, using the main databases. The PPARGC1A gene plays an important role in a number of physiological processes and is responsible for the metabolism of glucose and ATP, to a greater extent in muscle tissue; for oxidative processes in organs; and for switching one or another type of muscle fibers depending on the force load. It was proved that the expression of this gene can be induced under the influence of low temperatures. The PPARGC1A polymorphism has different effects on athletic performance, depending on its alleles. For example, the Gly allele, associated with muscle strength and endurance, favors athletic performance, while the Ser allele and the Ser-Gly genotype show no significant evidence. The results of our review are intended to help select a training strategy for each athlete in order to understand the role of environment and genotype in achieving athletic success.