The high level of potential seismic hazard in the southern regions of Ukraine requires the state support for the development on their territory of quite dense network of seismological and engineering seismological observations. The results of seismic micro zoning give as a more accurate picture of the seismic situation in the Odessa region and Odessa city. Further development of the monitoring network is necessary for solving of the problem of relatively cheap, but highly effective, seismic protection of population, environmentally hazardous and economically important objects.