There has been a steady increase in the prevalence of HTN -more than doubled as compared to 1998 and by 170% -compared to 2000. The prevalence of HTN among circulatory diseases (CD) in adults is 46.8%, i.e. almost half of patients with CD have high BP [7,9].In Ukraine, according to epidemiological studies, the age-adjusted prevalence rate of HTN in the urban population is 29.6% for both men and women. In the rural population the prevalence of HTN is higher -36.3%, including 37.9% -among men, and 35.1% -in women.Based on data of the Ministry of Health, when analyzing the HTN structure by the level of BP, 50% of patients had arterial hypertension (AHT) of the 1 st level, every third -AHT of the 2 nd level, and every fifth -AHT of the 3 rd level [7].Among those with high blood pressure 67.8% of rural and 80.8% of urban residents are aware of the presence of the disease, 38.3% and 48.4% are treated, and the treatment efficiency is 8.1% and 18.7%, respectively. Thus, the situation as to the AHT monitoring is unsatisfactory in both rural and urban population, but it is extremely unfavorable in rural areas [6].Based on the data from a largescale meta-analysis it has been confirmed that the first line drugs for treating HTN are diuretics (thiazide and thiazide-like) (the main mechanism of action of thiazide diuretics is the rapid elimination of sodium and potassium ions, thus achieving maximum excretion of liquid from the body that leads to decrease of BP), angiotensinconverting-enzyme inhibitors L.V.Iakovlieva -professor, Doctor of Pharmacy, head
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