A genetic screening test for obesity based on stochastic sensing was proposed. Stochastic sensors designed using different carbon matrices were used. The genes selected were: plasminogen activator inhibitor 1 (PAI-1) and leptin. The two genes can be reliably detected in whole blood samples. The linear concentration range was between 1.25 × 10 −10 and 1.25 × 10 −3 mg/mL for leptin, and between 1.00 × 10 −12 and 1.00 × 10 −5 mg/mL for PAI-1. The main advantages are: the sample did not need any pretreatment before measurement; the limits of determinations achieved for leptin (1.25 × 10 −10 ) and PAI-1 (1 × 10 −12 ) are low, and the screening test is fast and reliable.
Objective. The purpose of this study is to analyse histopathological and clinical characteristics of EOCRC. Colorectal cancer was formerly considered as a disease of senescent age; in the last years, it is a noticeable trend of growing incidence among young people (aged between 20 and 45 years). Few of newly diagnosed cases are inherited and most of them are sporadic. Material and method. The authors studied retrospectively a series of 33 cases of early onset colorectal cancer, 17 men and 16 women, with ages below 45 years, admitted between January 2009 and January 2015 in II and IV Surgical Wards of Emergency University Hospital Bucharest. Results. Colorectal cancer in young adults tends to be an aggressive disease with dominant distal location (68.5% of all cases), mostly adenocarcinomas (96.6%) with moderate to poorly differentiated types (51.4% G2 and G3), diagnosed in advanced stages (57.6% stages III and IV), with high frequency of complications (33% presented with peritoneal carcinomatosis and 9% died during hospitalization). Conclusions. EOCRC is a heterogenous group regarding etiopathogeny, localization and histopathological features of the tumor, with aggresive histopathological types, diagnosed in advanced stages. It may be necessary to elaborate new screening protocols for colorectal cancer in young adults and to fi nd clinical and biological markers that are indicating high-risk patients.
Recent studies showed that iron deficiency anemia was correlated with ischemic stroke in patients with carotid artery stenosis. It was also identified as the culprit of ischemic stroke in patients without any acknowledged risk factors for stroke. We presented a clinical case that highlights the importance of the management of anemia as etiologic factor of ischemic stroke, both as primary and secondary prevention.
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