This study was specifically embarked upon to establish empirically the relationship exiting among Exchange rate, Interest rate and economic growth in Nigerian economy over the period of 1970-2010. Fundamentally, the period of the study was fractured into two prominent distinctions of economic era-the regulation era and the deregulation era. The study adopted vector auto-regression (VAR) technique, with specific emphasis on Impulse Response factor and the Forecast Error Variance Decomposition.