Aims To gauge the effect of disease state and disease progression on the glucuronidation and sulphation of paracetamol (APAP) among HIV-positive patients and patients with AIDS. Methods The extent of APAP glucuronidation and APAP sulphation was assessed using a spot urine sample collected 4 h after the oral administration of 500 mg of APAP to 108 patients with AIDS or HIV infection. The molar concentrations of APAP and its glucuronide and sulphate metabolites were determined using a validated h.p.l.c. method and glucuronidation and sulphation indices were constructed using APAP metabolite/APAP molar concentration ratios. Results No effect of disease state, AIDS vs asymptomatic HIV positive vs control, on APAP glucuronidation or sulphation was observed. The patient population was studied over time and disease progression also did not significantly alter the calculated glucuronidation and sulphation indices. The effect of the concomitant administration of other therapeutic agents was assessed and in the cross sectional portion of the study dapsone appeared to significantly decrease APAP sulphation as did lamivudine. In the longitudinal portion of the study the latter effect was not observed but zidovudine was seen to increase APAP glucuronidation. The data also indicates that APAP glucuronidation may be reduced in patients who are >10% below their ideal body weight.
The news that Dr. D.S.N Raju, former Deputy General Manager (DGM) of Oil and Natural Gas Commission (ONGC), Dehradun, a renowned micropaleontologist and biostratigrapher left for heavenly abode on 11 th May 2021, was a shock to one and all who knew him. A great teacher, scholar and a passionate geologist, Dr. D.S.N. Raju died at his Rajahmundry residence after a brief illness. He was a kind hearted and wonderful person with never-ending curiosity for geological studies. With his dedication and hard work, he determined to leave his legacy summarized in books, charts and papers to the next generations and he succeeded in this to a large extent. Till the time he could move around, he was collaborating with Professors and Scientists across the globe at his personal lab working tirelessly on Lexicon (INDPLEX) for the geological formations on Indian sedimentary basins. He was addicted to micropaleontology till his last breath. His contributions in geological studies will continue to guide hydrocarbon exploration in the Indian basins for a long time to come.Born on 01.07.1938 at Yelurupadu in West Godavari district, Andhra Pradesh, he was the second son of Lt. Mr. Datla Venkatanarasimha Raju and Lt. Mrs. Datla Buchirajaiah. Dr. D.S.N. Raju had his earlier education at Yelurupadu and topped the SSLC exam and intermediate in the DNR College at Bhimavaram. He desired to study philosophy and secured a seat in Santiniketan (Kolkata). However, as destiny would determine, his family members weighed in and changed his mind on the verge of boarding the train to Howrah at the Tadepalligudem railway station. Then, he applied for B.Sc. (Hons.
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