The choice of drugs in traumatic injuries of the head is one of the most complex problems in the complex treatment of such patients. The aim was to estimate the cerebroprotective action of Ademol on the indicator of lethality of rats against the background of an experimental traumatic brain injury (TBI). The experimental model of the TBI of severe severity was caused by the action of the flow of carbon dioxide under pressure that was created using a gas cylinder pneumatic gun. The therapeutic effect of Ademol on the model TBI was evaluated at doses of 1, 2 and 4 mg/kg intravenously. Pseudo-operative animals and control group received a 0.9% NaCl solution at a dose of 2 ml/kg. The results were processed using the statistical program StatPlus 2009. Used Fisher angular transformation when accounting for results in an alternative form. In the course of the experiment, it was found that in the control group at the end of the experiment, 8 days after the TBI model, death of 90% of the rats was recorded p<0.05. Ademol showed the highest protective effect on the brain at a dose of 2 mg/kg where the death of rats was 30% on the 8th day of the experiment. The obtained data indicate that among the studied doses 1; 2 and 4 mg/kg is conventionally effective at just 2 mg/kg, in which Ademol exhibited the highest neuroprotective activity (p<0.05).
In view of the absence of natural resources of spinel for obtaining magnesia-spinellide refractories, it is synthesized using the methods of solid phase reactions, melting in arc furnaces, coprecipitation, drying and washing, pyrometric atomization, etc. According to us, the first two methods are the most promising ones for its industrial production.At the Ukrainian Scientific-Research Instltute of Refractories, we studied the synthesls of magnesia-alumina spinel from periclase and alumina and established t~e main technological parameters for producing spinel-based components; testing of the components obtained from the spinel showed that they are suitable for various thermal units [i-71. We note that in many countries, extensive studies are being carried out for synthesizing magnesia-alumina spinel that can be used either directly or in the production of refractories.Teoremi and Ciocca [8] indicate that when carrying out solid phase synthesis, calcinated alumina and sintered magnesia are the most suitable sources for AI20 a and MgO, respectively.Various additives are introduced in order to accelerate synthesis.In view of the problems related to the availability of the raw materials, it is advisable to carry out the synthesis of magnesia--alumina spinel using periclase and buaxite.We studied the effect of the main technological parameters of synthesis of the spinel (the bauxiteto-periclase ratio, the compaction pressure, the firing temperature, and the mineralizing additives) on its properties. Tables 1 and 2 show the characteristics of the raw materials.The magnesia raw material consists of 90-92% periclase and 6-10% silicates (mainly, forsterite).In both samples, periclase is present in the form of yellowish isometric and polygonal grains having normal refractive indices.The maximum and the predominant grain size of periclase amount to i00 and 20-40 pm, respectively.The bauxites are characterized by inhomogeneity; the bauxite samples have different colors indicative of the differences in their chemical and mineralogical composition.The main components of bauxites include corundum exhibiting different degrees of crystallization, a transparent glassy substance containing acicular mullite crystals measuring 4-6 x 10-12 pm, and the titanium-containing minerals, viz., tialite AI203 .TiO 2 and anosovite TiaO 5,
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