In experiments with mice under various models of acute hypoxia a new synthesized compound LKhT 3-21 (50 mg/kg) showed a distinct antihypoxic activity. In comparison to mexicor (50 mg/kg), this compound increased lifespan in a hermetic chamber, under hemic hypoxia and histotoxic hypoxia by 107 %, 47 %, and 70 %, respectively. LKhT 3-21 exceeded mexicor in the effect against acute normobaric hypoxia with hypercapnia (in 1.9 times), acute hemic hypoxia (in 1.4 times) and acute histotoxic hypoxia (in 1.6 times).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.