The aim of this work was to study the relationship between changes in blood platelet sialic acid levels and adenine nucleotide pool regulation with the parameters of platelet hemostasis (adhesive-aggregation and retractile capacity of blood plates) in chronic myeloleukemia and idiopathic myelofibrosis. The studies were performed on platelets of healthy subjects (20), patients with chronic myeloleukemia (14) and idiopathic myelofibrosis (11) with advanced clinical manifestations.
One third of patients with myelodysplastic syndrome die before the development of leukemia from infectious and hemorrhagic complications; after the onset of acute myeloleukemia this figure reaches 59%. Therefore, the relevance of studying hemostatic disorders in preleukemic conditions is dictated primarily by the need to preserve the lives of patients. Literature data indicate the absence of significant changes in the plasma-coagulation component of hemostasis and fibrinolytic processes. At the same time, hematopoietic dysfunction in myelodysplastic syndrome necessarily includes megakaryocytic bone marrow, which cannot but affect the functional state of the platelet apparatus, the assessment of which was the main task of this work.
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