Ichthyosis is an infrequent clinical entity worldwide (1:300,000 births) that produces visible scales on all or a great part of the skin surface. The new classification of this weird dermatosis is divided into 36 groups and their subgroups depend on their frequency, heritage and extracutaneus manifestations. Among the autosomal recessive congenital ichthyosis, we can identify collodion baby, which describes a newborn, preterm most of the time, with a hard, tense, brilliant membrane covering the whole body. In this article we talk about the case of a collodion baby, preterm female newborn of 35 gestational weeks, attended at Hospital General del Sur, Choluteca, Honduras, whose mother had poor prenatal control, not performed by a physician, without obstetric ultrasound during pregnancy. At physical examination the new-born had a constrictive, tense membrane, similar to an oily parchment or collodion that covered the entire body surface, she was given the initial optimum management, but due to lack of service in the area of pediatric dermatology, neonatology and genetics, the decision to transfer the newborn to a hospital with a higher level of care was made. In Honduras this case would be the second reported in the country and the first in the southern region of the country.
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