The aim of this experimental study is to compare the biointegration and tissue response to different surgical mesh types, inserted in various layers of the abdominal wall of Wistar rats. After 30 days, the rats were sacrificed and the meshes were removed en bloc with the subcutaneous tissue, muscular layer and peritoneum. Tissue response (fibrosis, inflammation) was measured using quantitative and semi-quantitative morphometry. We observed that polyethylene terephthalate 3D mesh induces significantly more fibrosis compared to polypropylene mesh and the fibrosis is absent or minimal in case of the control group. Tissue reaction, including fibrosis, is reduced around the polypropylene mesh. We also observed that fibrosis is more intense towards aponeurosis and peritoneum. We can conclude that the 3D mesh shows better biointegration if it is used in proper circumstances. It�s well tolerated by the organism if sutured to the aponeurosis and preferable with monofilament stitches.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.