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Ríos, E.; Cholich, L.; Silva, J.; Acosta de Pérez, O.: Histopathological lesions in central nervous system of goats poisoned by Ipomoea carnea. Rev. vet. 19: 2, 130-134, 2008. Ipomoea carnea var. fistulosa (Convolvulaceae) is a perenne poisonous plant, found throughout the Argentine Northeastern. The intoxication produces a lysosomal storage disease in goats, sheep and cattle. Five goats were fed with 50 g/kgBW/day of fresh leaves, flowers and stems of I. carnea, during 43-60 days. Hirsute coat, depression, difficulty to stand up, ataxia, hypermetria, wide-based stance, incoordination of muscular movements, intense tremors, spastic paresis, abnormal postural reactions, nystagmus, hyperreflexia, hypersensitivity to sound, head tilting and loss of equilibrium were observed in all treated animals. The histopathologic study revealed the presence of cytoplasmatic vacuolation mainly in medulla oblongata and cerebellum. Control animals did not show any alterations. We conclude that this poisoning causes central nervous system damage, being Purkinje cells the most severely affected.Key words: goat, intoxication, Ipomoea carnea, nervous system lesions. ResumenRíos, E.; Cholich, L.; Silva, J.; Acosta de Pérez, O.: Lesiones histopatológicas en sistema nervioso central de cabras intoxicadas con Ipomoea carnea. Rev. vet. 19: 2, 130-134, 2008. Ipomoea carnea var. fistulosa (Convolvulaceae) es una planta tóxica, perenne, distribuida en el nordeste de Argentina. La intoxicación produce una enfermedad de almacenamiento lisosomal en cabras, ovejas y bovinos. Cinco cabras fueron tratadas vía oral con 50g/kg/ día de hojas frescas, flores y tallos de I. carnea, durante 43-60 días. En todos los animales tratados se observó pelo hirsuto, depresión, dificultad en la estación, ataxia, hipermetría, aumento de la base de sustentación, incoordinación de movimientos, intensos tremores, paresia espástica, reacciones posturales anormales, nistagmo, hiperreflexia, hipersensibilidad a los sonidos, cabeza inclinada y pérdida de equilibrio. El estudio histopatológico reveló la presencia de vacuolización citoplasmática principalmente en medula oblonga y cerebelo. Los animales controles no mostraron anormalidades. Se concluye que la intoxicación por I. carnea provoca daños en el sistema nervioso central, resultando las células de Purkinje las más severamente afectadas.

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Bothrops alternatus venom was intramuscularly inoculated (3 mg/kg) into 12 dogs, 30 to 65 days old. Spontaneous bleeding commenced twenty minutes later. Blood samples obtained 3 and 20 minutes after venom inoculation presented spontaneous clotting formation. Plasmatic fibrinogen decreased within 3 minutes. Partial thromboplastin time (PTT) and one-stage prothrombin time (PT) were found. Plasma did not coagulate 40 minutes after inoculation. Platelet counts did not vary but their function was altered. Histopathology pointed out severe muscular necrosis and massive hemorrhage in the inoculation area. Regional ganglia showed intense hemorrhage. The 45 and 65-day-old animals showed alveolar thickening of the septum and generalized congestion, but the 30-day-old animals showed thrombosis of small arteries and arterioles. Renal lesions were different with the age. Cortical tubular necrosis was present in puppies, and intense cortical tubular hydropic degeneration was present in adult dogs. Thymus hemorrhage and necrosis were present

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