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Alzheimer's disease (AD) is a serious medical and social problem of our time, while remaining the most common cause of dementia in the elderly. The leading symptom in the clinical picture of the disease is a progressive loss of memory with further development of behavioral disorders. In the early stages of AD, patients are mostly managed by neurologists and differential diagnosis is carried out with a variety of neurodegenerative diseases. The authors present clinical criteria of AD diagnosis and consider diagnostic possibilities in the predementia stage using biological markers. With this purpose, modern concepts of the etiology and pathogenesis of AD and genetic aspects of pathology are considered. Contribution of many environmental factors to the initiation and progression of the disease process is evaluated. Mechanisms of cerebral amyloidosis and its characteristic neurological manifestations are considered.

The pandemic of the new SARS-CoV2, that started at the beginning of 2020, caused a catastrophic increase in morbidity and mortality in early 2020 and posed a number of challenges for healthcare system. Primarily, this concerns the study of the effect on different organs and systems, that new virus can exhibit. This knowledge further can serve as a key to the development of effective methods for the prevention and treatment of COVID-19 associated pathological conditions. The objectives of this review include the analysis of neurological complications caused by the new coronavirus infection and the determination of the possible mechanisms of the virus’s effect on the human nervous system.

TLT has a positive effect on the basic patterns of IS pathogenesis and biochemical predictors allow to rationalize the treatment.

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We have studied the influence of kopaxon on the structure of lipid phase of cellular membranes of red corpuscles, the condition of process of peroxide lipids oxidation and the system of antioxidative defence of 58 people with remittent form of multiple sclerosis. On the grounds of analysis of dynamics of laboratory index, membrane stabilized effect of this preparation was proved.

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