Деменция с тельцами Леви (ДТЛ) является одной из самых частых причин деменции пожилого возраста. В популяции старше 65 лет встречаемость ДТЛ составляет около 0,7%, а среди лиц старше 85 лет достигает 5% [1, 2]. В нозологической структуре деменций ДТЛ занимает 4-е место после болезни Альцгеймера, смешанных деменций и сосудистой деменции, на ее долю приходится около 5-10% всех случаев деменции [2, 3]. Клинически ДТЛ проявляется прогрессирующим корково-подкорковым когнитивным дефицитом,
Asthenia is a clinical syndrome that can be manifest in almost all somatic, infectious, and neurological diseases. Initially a protective mechanism indicating depletion of energy resources, asthenia can become a pathological and extremely disabling condition, and can even progress to an independent immune-mediated disease -chronic fatigue syndrome. Asthenia is often combined with affective and cognitive disorders, producing diagnostic diffi culties. The article addresses the complex interweaving of asthenia, chronic fatigue syndrome, and cognitive and affective disorders.
Behavioral and psychological symptoms of dementia can manifest at various stages during the disease. Prominence and rate of progression may depend on nosological form of dementia as well as environmental factors, concomitant diseases et al. Each psychiatric symptom is based on the specific neurotransmitter imbalance and differentiated involvement of various parts of the Central Nervous System in the pathological process. Treatment in each case should be chosen individually taking into account the balance of benefits and risks of prescribed drugs.
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