This research aimed to study the human capital, innovation awareness, social responsibility and human resource success. The samples included 243 entrepreneurs selected from small and medium enterprises in Buriram province, Thailand. The research consisted of correlation analysis and regression analysis. The result showed that 1) The human capital and innovation awareness were positive to human resource success, and 2) The social responsibility had not positive effects on the success of human resource management in the SMES (model4). The result of this research provided useful suggestions for more effective management of human resource within the context of small and medium enterprises in Buriram Province, Thailand.