BACKGROUND: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder mediated by inflammatory cytokines. Decreasing vitamin D levels is a common feature in SLE patients. Vitamin D has the capacity in suppressing inflammatory cascade. Seluang fish (Rasbora spp.) contained a high level of vitamin D with the potential as a new therapeutic modality. AIM: This study aimed to assess the efficacy of Seluang fish oil against proinflammatory cytokines, vitamin D levels, and clinical conditions of SLE. METHODS: A randomised, double-blind, clinical trial study design was conducted. The subjects were 16 SLE subjects treated with 500uL Seluang fish oil capsules and 16 SLE subjects with placebo capsules. Measurement of vitamin D, IL-1, IL-6 and IL-17 levels were performed with ELISA. Clinical assessment of SLE was performed with MEX-SLEDAI. Bivariate analysis, T-test, was performed. Data were presented in the form of mean ± SD. RESULTS: The administration of Seluang fish oil was clinically able to show efficacy assessed by the MEX SLEDAI score. Significant results were also shown by increased vitamin D levels and reduced levels of IL-1, IL-6 and IL-17, in Seluang fish oil group. CONCLUSION: Seluang fish oil possessed the efficacy of reducing the inflammatory response in SLE patients by increasing serum vitamin D levels.
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which usually affects multiple organ systems. Its patients are prone to hypovitaminosis D along with its complications such as osteoporosis. The improvement of vitamin D status in SLE patients is associated with better immune modulation, proinflammatory cytokine suppression, calcium absorption improvement, as well as better severity and lower osteoclastogenesis. This double-blind, randomised clinical trial was conducted in the Allergology-Immunology Polyclinic in the Internal Medicine Department of Mohammad Hoesin General Hospital, Palembang, Indonesia, over the period April 2017 – February 2018. Samples were given either seluang (Rasbora agrotyenia) fish oil or placebo for 12 weeks. On the start and the end of the study, vitamin D levels were examined. 32 patients, all female, were divided evenly into the two groups. On the end of the study, the seluang oil group had significant vitamin D increase compared to placebo (p = 0.000). We concluded that the administration of seluang fish oil was able to increase vitamin D levels in SLE patients.
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