Pepper of the Capsicum species is a common ingredient in various food preparations by different cultures worldwide. The Capsicum is recognised by its five main domesticated species, namely Capsicum annuum, C. baccatum, C. chinense, C. frutescens and C. pubescens. The genetic diversity in Capsicum offers fruits in wide ranges of morphology and carotenoid profile. Carotenoids enhance the value of pepper from a nutritional standpoint, despite being commonly prized for the pharmacologically active pungent capsaicinoids. Carotenoids of pepper comprise mainly of the unique, powerful and highly stable capsanthin and capsoroubin, together with β-carotene, β-cryptoxanthin, lutein, zeaxanthin, antheraxanthin and violaxanthin. These carotenoids are present at diverse profile and varying levels, biosynthetically connected to the fruit maturity stages. This review describes the health-promoting functional attributes of the carotenoids that are mainly associated with their excellent role as lipophilic antioxidants. Capsicum as a great source of carotenoids is discussed in the aspects of main domesticated species, biosynthesis, pigment profile, antioxidant activity and safety. Findings from a number of in vitro, in vivo and clinical studies provided appreciable evidence on the protective effects of pepper’s carotenoids against degenerative diseases. Hence, pepper with its functional carotenoids might be recommended in health-promoting and disease preventing strategies.
Despite the major anatomical importance of the human ilium in medicine and forensic investigations, little is understood about its pattern of growth. This study was conducted to investigate the changes in the surface area of the human ilium from birth through to adolescence in 80 human ilia. A photographic image of the pelvic surface of each bone was taken and examined using an image quantification package. The surface areas of four regions of interest were quantified: the auricular, post-auricular (PA), iliac fossa, and whole pelvic surface of the ilium. The results highlight a rapid increase in surface area for all regions in the first few years after birth which continues, albeit at a slower rate, until 4 years of age when the rate of growth is further reduced. Although the ilium and its various components continue to grow between 5 years and puberty, the rate of growth is markedly reduced until puberty when growth of the pelvis again increases. Interestingly, analysis of the differential growth of the auricular region compared with the PA region throughout development suggests that the PA region exhibits more advanced growth. This may indicate that its role in structural development for the purposes of preparation and maintenance of bipedal stance and locomotion may have been previously poorly understood. Anat Rec, 296:1688Rec, 296: -1694Rec, 296: , 2013. V C 2013 Wiley Periodicals, Inc.Key words: ilium; auricular; post-auricular; growth; developmental milestone; juvenile; ageThe human ilium is a flat, irregularly shaped bone with three surfaces: gluteal, pelvic, and acetabular. The pelvic surface can be divided functionally into two regions: a large ventral iliac fossa to accommodate the attachment of the large iliacus muscle, and a smaller thickened dorsal part for the articulation with the sacrum. This posterior region can be further subdivided into a ventral articular (auricular) surface and a dorsal nonarticular (post-auricular (PA)) surface which is primarily for ligamentous attachment. The gluteal surface is a relatively unremarkable expansive area well suited to accommodate large muscle attachments and it is this functional, even antagonistic, muscular interaction on both sides of the iliac blade that is reported to be the principal driver of bone formation during the early developmental period (Gardner et al., 1969;Last, 1984;Delaere and Dhem, 1999).The primary ossification center for the ilium appears superior to the greater sciatic notch, around two to three intrauterine months (Laurenson, 1964). Ossification then expands via periosteal apposition of cortical bone toward the metaphyseal growing surfaces of the cartilaginous anlage (Delaere et al., 1992;Cunningham and Black, 2009a). In contrast to the intramembranous origin of the external cortex, the internal cancellous structure of the ilium is formed via endochondral ossification.
The integration of human knowledge between the medical and health care sciences with revealed knowledge was established since the era of Al-Razi (Rhazes), Ibn Sina (Avicenna), Ibn Rushd (Averroes), AlZahrawi (Albucasis) and others. However, the glorious period of Islamic medicine gradually declined after the period of 'Abbasiyyah and 'Uthmaniyyah. At present, many scholars tend to separate the modern medicine and the revealed knowledge, resulting in the disconnection between these two fields. There is little to suggest the presence of reference collections that integrate the Qur’an and Hadith with medicine. This review aimed to fill that gap. Relevant Qur’anic verses and authentic Hadith of the Prophet Muhammad (peace be upon him; henceforth PBUH) in relation to a specific field in medicine i.e. the anatomy of human musculoskeletal system was extracted. The musculoskeletal system is unique in which it forms the ‘backbone’ of normal human posture. The system plays a vital role in maintaining human daily activities. From this review, it is noted that many Qur’anic verses and Hadith relate to the musculoskeletal system. A few examples include the number human joints and its relationship with the daily prayers (Salah), the daily charitable act recommended to all Muslim, the coccyx bone that is indestructible and shall be the source for human resurrection during the hereafter, and others. These examples necessitate for a more in-depth analysis to enlighten the revealed knowledge from the medical perspective.
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