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Recent advances in practical applications of metallophthalocyanines (MPcs) at different technological fields have stimulated us to design and synthesize a new asymmetric AB3-type trimeric zinc(II)-phthalocyanine (1). This bulky and high...

Novel 4,4'-(((2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diyl)bis(2-methylpropane-2,1-diyl))bis(oxy)) (SUBO) bridged ball-type metallophthalocyanines were synthesized starting from 4,4'-(((2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diyl)bis(2-methylpropane-2,1-diyl))bis(oxy))diphthalonitrile with convenient metal salts in 2-N, N-dimethylaminoethanol. The new bisphthalonitrile compound was obtained from 2,2'-(2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diyl)bis(2-methylpropan-1-ol) and 4-nitrophthalonitrile in acetonitrile...

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The mononuclear coordination compounds, [Zn(L)Cl2] (1), [Pd(L)Cl]Cl (2), and [Pt(L)Cl]Cl (3) (L) is a tridentate‐coordinated of 4‐(6‐hydroxyphenyl)‐2,6‐di(thiazol‐2‐yl)pyridine) were synthesized and characterized by different spectroscopic methods (FTIR, MALDI‐TOF‐MS, 1H NMR, 13C NMR, and UV/Vis). By using density functional theory (DFT) and time‐dependent DFT (TD‐DFT) methods, the geometrical parameters, UV/Vis absorption spectra, and infrared vibrational frequencies for the investigated compounds were explored. Anticancer activities of these compounds were determined by SRB viability assay in human lung (A549 and H1299), prostate (LNCAP), colorectal (HT‐29), breast cancer (MDA‐MB‐231) and healthy bronchial (BEAS‐2B), breast (MCF‐10A), colon (CCD‐18Co), and prostate (WPMY‐1) epithelial cells. Caspase 3/7 activity, cleaved cytokeratin‐18, and PARP levels were measured to determine apoptosis in the metal compounds found to be effective. Among the compounds, 1 showed a selective inhibiting effect and induced apoptosis on the cancer cells, thus further analyses are needed to evaluate its antitumor/anticancer activity.

A new unsymmetrically substituted 2,2'-bipyridine ligand, 5-methyl-5'-carbomethoxy-2,2'-bipyridine (L) was isolated from the dry distillation of the copper(II) complex, monoaqua-bis(trans-5-methyl-pyridine-2-carboxylato-N,O)copper(II). The ligand was fully characterized. The spectroscopic and single-crystal X-ray diffraction (SCXRD) studies of the coordination compounds of the ligand with platinum(II) and silver(I); cis-Pt(L)Cl2 (1) and [Ag(L)2]PF6 (2), respectively are reported. In 1, the Pt centre coordinates to tertiary N atoms of the ligand and two chloride ions to form a neutral square-planar coordination sphere, while in 2, the Ag(I) centre is coordinated by two ligands through N atoms to generate a cationic flattened tetrahedron geometry in which two mean planes intersect each other at 50.93°. The pyridine rings are nearly coplanar as revealed by the torsion angle [N1-C5-C6-N3] of 0.32°. In both complexes, L acts as a chelating ligand through pyridyl N atoms. In 1, the molecular units are stacked in a head-to-tail fashion with a Pt•••Pt separation of 3.5 Å. Supramolecular self-assembly of the molecular units by extensive intermolecular contacts through C-H•••Cl and C-H•••O between the adjacent units results in an infinite two-dimensional flattened-out herringbone structure in the crystalline state. In 2, the molecular units are interconnected with each other by C-H•••O contacts between the adjacent units running parallel to each other. Both complexes are fluorescent in solution and have emission maxima in the UV-Vis regions, which is a very important property for optoelectronic applications. DFT (density functional theory) and TD-DFT (time-dependent-DFT) calculations were performed at B3LYP/6-311+G(d,p)/LANL2DZ level to explore structural, electronic, and spectroscopic properties to compare with the experimental results. The molecular orbitals (MOs) were carried out with DFT at the same level.