AbstrakTujuan penelitian ini adalah untuk mengetahui efektivitas krim ekstrak buah naga merah (Hylocereus polyrhizus) dalam meningkatkan jumlah sel fibroblas luka bakar derajat II pada tikus putih (Rattus novegicus). Dua puluh ekor tikus putih (Rattus novegicus) jantan dibagi menjadi lima kelompok perlakuan dengan jumlah empat ulangan setiap kelompok. Semua tikus tersebut diinduksi dengan luka ba kar derajat II. Kelompok kontrol negatif (K-) diterapi dengan basis krim minyak dalam air, Kelompok kontrol positif (K+) diterapi dengan Bioplacenton ® , kelompok perlakuan diterapi dengan krim ekstrak buah naga merah (Hylocereus polyrhizus) dengan konsentrasi P1 7.5%, P2 15%, dan P3 30%. Terapi diberikan dua kali dalam sehari selama 10 hari. Hasil uji Kolmogorov-Smirnov menunjukkan data terdistribusi normal (p>0.05) dilanjutkan dengan uji Oneway ANOVA yang menunjukkan adanya perbedaan nyata dari tiap kelompok perlakuan (p<0.05) dan dilanjutkan dengan uji Post-Hoc LSD. Rata-rata jumlah fibroblas setiap kelompok perlakuan menunjukkan bahwa kelompok K-dan K+ berbeda nyata dengan kelompok P1, P2 dan P3. Jumlah sel fibroblas terbanyak didapati pada kelompok P2. Kesimpulan dari penelitian yang telah dilakukan adalah krim ekstrak buah naga merah (Hylocereus polyrhizus) dapat meningkatkan jumlah sel fibroblas luka bakar derajat II pada tikus putih (Rattus norvegicus). AbstractThis study aimed to find out the effectiveness of red dragon fruit (Hylocereus polyrhizus) extract cream in increasing amount of fibroblast cells in second degree burns in white rats (Rattus norvegicus). Twenty male rats (Rattus novegicus) divided into five treatment groups with four repetitions respectively. All of them were induced with second degree burns. Negative control (K-) group treated with oil in water cream base. Positive control (K+) treated with Bioplacenton ® . P1, P2 and P3 group treated with 7.5%, 15% and 30% red dragon fruit (Hylocereus polyrhizus) extract cream. Therapy was given twice a day for 10 days. Kolmogorov -Smirnov test showed that the data distribution is normal (p>0.05), continued with Oneway ANOVA test that showed significant different from each groups (p<0.05) and continued with Post-Hoc LSD test. Average amount of fibroblast cells from each groups showed that K-group and K+ group is significanly different from P1, P2 and P3 group. P2 group showed the highest fibroblasts amount. The conclusion of this study is red dragon fruit extract (Hylocereus polyrhizus) cream can increase the amount of fibroblast cells in second degree burns in white rat's (Rattus norvegicus) skin.
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