No abstract

Designing new inhibitors having less side effects is a need which also could reduce cholesterol levels. To fulfill this aim, we have carried out a molecular docking study toward 3‐hydroxy‐3‐methyl‐glutaryl‐CoA (HMG‐CoA) reductase. A set of designed structural derivatives of statin drugs, eight ligands which are used as HIV‐1 integrase inhibitor candidates, a set of terpenoids, and ligands downloaded from Zinc15 database were docked to HMG‐CoA reductase enzyme which contains atorvastatin in crystal structure. The analysis of docking studies revealed that statin derivative ligands are more appropriate for inhibition of HMG‐CoA reductase. To define the contribution of the molecular properties to the binding of ligands to enzyme structure; the highest occupied molecular orbitals‐lowest unoccupied molecular orbitals, hardness, electronegativity, and chemical potential properties of ligands have best score in their sets calculated by quantum mechanical tools.

Aim: The aim of this research is to investigate the relationship between rational drug use and healthy lifestyle behaviours of university students. Method: This descriptive and cross-sectional study consisted of 1115 students from a university in the Southeast-East Anatolia Region in the autumn semester of the 2019–2020 academic year. In the collection of data, ‘Student Introduction Form’, ‘The Rational Drug Use Scale’ and ‘The Health-Promoting Lifestyle Profile II’ were used. Ethical approval was obtained from the Batman University Ethics Committee. In addition, necessary legal permissions were obtained from the institution where the study was conducted and from the students. Descriptive statistics, number, percentage, independent t-test, ANOVA test and Spearman’s rank correlation were used in the Statistical Package for Social Science (SPSS) 22.0 package software to analyse the data. Results: The average age of the students was 21.31 ± 2.37 years, and their monthly drug expenditure was 142.63 ± 157.200 Turkish Lira. Some 28.1% of them were third-year students, 59% had graduated from Anatolian high school, 59.6% were living with their nuclear family, 49.1% had an equal level of income and expenditure, 7.7% had no chronic disease, and 9% had regular medication. Some 57.8% of them had health insurance. The Health-Promoting Lifestyle Profile II scale mean score of the students was 124.12 ± 21.37 and the Rational Drug Use Scale mean score was 33.65 ± 6.75. A statistically significant difference was found between the students’ class, income, and the total mean scores of the health-promoting lifestyle profile II scale ( p < 0.05). A statistically significant difference was found between the school type, family type and income status of the students and the total mean scores of the rational drug use scale ( p < 0.05). Conclusion: A strong positive correlation was found between rational drug use scale and the health-promoting lifestyle profile II scales.

Background: Adopting healthy lifestyle behaviors is an important step in preventing diseases.Objective: This study aims to determine healthy lifestyle behaviors, fasting blood glucose (FBG) levels, and waist circumference of employees in a public university in Turkiye.Methods: This descriptive study was conducted. A total of 191 academic and administrative staff were recruited for this study.We used sociodemographic data form and the Health-Promoting Lifestyle Profile II (HPLP II) for data collection. We measured and recorded each participant’s FBG (at least 8 hours), height, weight, and waist circumference in the data sheet.Results: Of the participants, 77% were aged under 40; 74.9% were male; 71.2% were administrative staff; 48.2% had FBG between 100-125 mg/dl.; 49.2% were within the normal BMI (Body Mass Index) range; 29.2% of women had a waist circumference greater than 90 cm, 25.2% of men had a waist circumference greater than 100 cm. The average HPLP II score of the participants was 128.67±18.51.Conclusion: It was determined that healthy lifestyle behaviors did not change according to age, that 48.2% of the participants had FBG between 100-125 mg/dl and were not aware of their blood glucose levels, that half of the participants were overweight and obese, and that waist circumference and FBG increased as BMI increased. The incidence of diabetes might be higher than predicted in guidelines in near future.International Journal of Human and Health Sciences Vol. 06 No. 04 Oct’22 Page: 383-392