Stroke dikenal sebagai masalah kesehatan yang menyebabkan kematian kedua dan sebagai penyebab kacacatan ketiga di dunia. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik pasien stroke iskemik periode Januari-Desember 2019 di RSUD Dr. H. Chasan Boesoirie Ternate. Desain penelitian ini adalah penelitian deskriptif retrospektif dengan pendekatan cross-sectional. Menggunakan teknik total sampling. Sampel pada penelitian ini adalah seluruh penderita stroke di RSUD Dr. H. Chasan Boesaoirie yang sudah memenuhi kriteria inklusi dan eksklusi periode Januari-Desember 2019. Dari hasil penelitian didapatkan bahwa pasien stroke iskemi paling banyak diderita oleh laki-laki sebanyak 62%, dengan rentan umur sekitar 51-60 tahun dengan presentase 50%. Memiliki kadar kolesterol total mendekati normal 50%, kadar LDL mendekati normal 50%, kadar HDL mendekati normal 50%, kadar TGA normal 69%. Dari hasil penelitian dapat disimpulkan bahwa mayoritas kasus stroke Iskemik yang didapatkan di RSUD Dr. H. Chasan Boesoirie ialah berjenis kelamin laki- laki, kelompok usia 51-60 tahun dan hasil profil lipid pada penelitian ini kebanyakan masih pada kadar mendekati normal.Kata Kunci : Jenis Kelamin, Profil Lipid, Stroke iskemik, Usia,
The utilization of the stems, leaves, and hulls of peanuts (Arachis hypogea) is not as popular as the seeds. This study aimed to investigate the chemical contents and pharmacological activities of A. hypogaea stems in-vitro and in-silico. This study was also completed with bibliometric analysis. The methanol extract (ME) was reextracted by ethylacetate to get ethyl acetate extract (EAE). The chemical contents of EAE were analyzed by phytochemical screening, Liquid Chromatography-Mass Spectroscopy (LC-MS/MS), TPC (Total Phenolic Content), and TFC (Total Flavonoid Content). In-vitro and in-silico studies evaluated antioxidant potency, toxicity, and cytotoxicity toward MCF-7 cell lines. The results showed that EAE contained terpenoids, flavonoids, alkaloids, and phenolics which were supported by LC-MS/MS data. The EAE was categorized as a very strong antioxidant and moderately active in both cytotoxicity and toxicity.
Soft coral Lobophytum sp is widely distributed in the waters of South East Sulawesi, Indonesia. However, no research data on the chemical and medicinal aspects of this genus from this region have been published. Therefore, this article aims to describe the findings of those aspects of Lobophytum sp. from this region. Ethyl acetate was used to extract the sample, and Vacuum liquid chromatography (VLC) was used to fractionate the ethyl acetate extract. The DPPH radicals and ABTS methods were used to assess antioxidant potency, the BSLT method was used to evaluate toxicity, and the Phytochemical test and LCMSMS method were used to determine the chemical composition. The results showed that the ethyl acetate extract was produced in seven fractions namely Fraction A-G. The weight of each extract was A (12.8% w/w), B (9.7%), C (10.1%), D (2.0%), E (7.0%), F (25, 3%) and G (11.5%). Further studies were carried out on the fraction F which was the fraction with the highest weight. Based on the level of antioxidant power proposed by Blois, the antioxidant potential of fraction F is a strong category with an IC50 value (μg/mL) 99.13 (DPPH) and 79.30 (ABTS). Fraction F is also not toxic with LC50 198.21 μg/mL. Those activities were supported by the qualitative phytochemical screening that exhibited the extract contains phenolic compounds. LCMSMS data indicated that fraction F of ethyl acetate extract contains fragransol D, lirioresinol A, neociwujiaphenol, phillygenin, pluviatelol, saurufuran B, β-hydroxyisovalerylshikonin and some unidentified compounds with molecular formulas C21H26O8, C23H26O8, C19H24O6.
Background: Though extensively studied in other Asian countries, office and home blood pressure (BP)-based hypertension determination and phenotypes in rural population are still scarcely investigated in Indonesia. We aim to elaborate this in an East Indonesia rural area, by implementing two available BP thresholds. Material and methods: The Ternate Sehat Indonesia (TENSI) pilot study obtained demographic, anthropometric, biochemistry, office and home BP data from 146 residents aged ≥ 18 years old living in Ternate Island from July-August 2022. Hypertension and its phenotypes were defined in accordance with the 2019 Indonesian Society of Hypertension (InaSH) and the 2017 American College of Cardiology/American Heart Association (ACC/AHA) BP guidelines. Office and home BP differences were analyzed within each participant's characteristics. Results: Mean mm Hg ± SD office and home (i) systolic BP were 121.8 ± 17.9 and 117.8 ± 14.8 mm Hg (p < 0.001), (ii) diastolic BP were 77.9 ± 12.1 and 74.7 ± 8.9 mm Hg (p < 0.001). Hypertension was evident in 26% (InaSH) and 34.2% (ACC/AHA) participants. Moreover, 17.4% (InaSH) and 24.8% (ACC/AHA) of those self-reported to not having hypertension were found to be hypertensives. The proportion of sustained, white-coat, and masked hypertension were 7.5%, 9.6%, 8.9% (InaSH), and 8.2%, 21.2%, 4.8% (ACC/AHA). Compared to office BP, home BP significantly differed throughout more characteristics. Conclusions: Our study has ascertained the actual hypertension status and phenotypes within a rural East Indonesia environment. The revelation of stronger home BP ability to detect BP differences may promote its application within the population in the future.
<p class="AbstractTitle"><em>One of the most popular diets today recommends a high protein- low carbohydrate diet as a weight loss strategy in obese patients. Diets high in protein appear to reduce appetite, energy intake, weight gain, and fat accumulation. The application of a high-protein diet has an impact on reducing the portion of other macronutrients, namely carbohydrates and fats. The purpose of this study was to determine the effect of a high protein, low carbohydrate and low fat (TPRKRL) diet on body health. With the focus of the analysis on changes in body weight, serum glucose and cholesterol levels in 22 male Wistar rat samples who were given the standard diet and the TPRKRL diet for 8 weeks. The results showed that there were no significant differences in the variables of body weight, serum glucose and cholesterol levels between the TPRKRL diet group and the control group (standard diet). In fact, the rats in the TPRKRL group experienced a relatively constant increase in body weight and glucose and cholesterol levels were susceptible to normal.</em></p><p class="AbstractTitle"><em>Keywords: high protein; body weight; glucose; cholesterol</em><em></em></p>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.