Movement control order (MCO) was enforced by the Malaysian government on 18th March 2020 due to sudden increase in the cumulative number of COVID-19 cases. University students, including medical students, were among the group of the population which were significantly affected. This study was conducted among medical students in Universiti Putra Malaysia (UPM) to compare the mental health status and coping strategies, between gender and phase of the clinical study related to their quarantine status between 18th March 2020 to 9th June 2020. This was a cross-sectional study involving the undergraduate medical students in UPM in the academic year of 2019/2020 during the MCO. A stratified random sampling method was used; a total of 173 respondents which includes students of Year 1 to Year 5 participated. The study was conducted after five months since the first day of MCO, for one week period of data collection. The mental health status was assessed using Depression, Anxiety and Stress Scale 21-item (DASS-21) questionnaire. Four-point Likert scale was scored to determine the degree of severity. The coping strategies was assessed using Brief-COPE (Coping Orientation to Problems Experienced) in which four-point Likert scale was used as well, and the total marks were grouped into four coping strategies. This study found higher scores of DASS-21 in the non-quarantined group and approach method was considered as a favourable coping strategy in both groups. In the quarantined group, female and clinical students showed higher scores of DASS-21. In the non-quarantined group, clinical students showed a significantly higher score of stress while male students significantly used their humour as coping strategies.
<p>Air pollutants are a major by-product of urbanisation and motorisation of society. In lower and upper middle-income Asian countries, in cities with rapid population growth such as Malaysia, traffic emissions are responsible for almost 90% of urban air pollution, so cycling or walking outdoor can be a major route of exposure for active commuters. Our study aims to examine the association between traffic-related air pollution and cardiorespiratory health symptoms among pedestrian and cyclists in a university campus located in Selangor, Malaysia. &#160;PM<sub>2.5</sub> concentrations were monitored using SidePak Personal Aerosol Monitor AM510 on weekday morning cycling and walking commutes into designated high and low-traffic areas nearby campus roadsides. Volunteers cycled (n=21) and walked (n=30) for about 60-minutes in high and low-traffic cycling and walking routes respectively. The cardiorespiratory health status of blood pressure and lung function were measured before, immediately after, after 15 minutes and after 1 hour of volunteers&#8217; commutes. The average commute exposure to PM<sub>2.5</sub> was determined, and the inhaled dosage was estimated. Results showed that pedestrian are exposed to higher PM<sub>2.5</sub> levels than cyclists traveling in the same high-traffic areas. However, the inhalation dose per kilometre travelled, D<sub>L</sub> (&#181;g/km) for cyclist was observed higher compared to the pedestrian due to the ventilation rate of physical activity. We also observed that there were increase in the systolic blood pressure and lung function (force-vital capacity-FVC) of pedestrians after the exposure to high PM<sub>2.5 </sub>concentrations at high traffic walking routes (61.6 &#177; 14.6 &#181;g/m&#179;). PM<sub>2.5</sub>&#160;concentrations while walking in the university campus were approximately three times higher compared to cities in Europe (26&#8239;&#956;g&#8239;m<sup>&#8722;3</sup>). Our observation techniques can be applied in resource-constrained countries with heavy traffic emissions that may have an impact on the health of active commuters. To characterise the exposure patterns of other traffic-related air pollutant surrogates (such as soot/black carbon and nitrogen dioxide) and their influence on acute and chronic health outcomes in different Asian traffic microenvironments, further research based on the results of our study is needed.</p>
The most prevalent cause of mortality and morbidity worldwide is acute coronary syndrome (ACS) and its consequences. Exposure to particulate matter (PM) from air pollution has been shown to impair both. Various plausible pathogenic mechanisms have been identified, including microRNAs (miRNAs), an epigenetic regulator for gene expression. Endogenous miRNAs, average 22-nucleotide RNAs (ribonucleic acid), regulate gene expression through mRNA cleavage or translation repression and can influence proinflammatory gene expression posttranscriptionally. However, little is known about miRNA responses to fine PM (PM2.5, PM10, ultrafine particles, black carbon, and polycyclic aromatic hydrocarbon) from air pollution and their potential contribution to cardiovascular consequences, including systemic inflammation regulation. For the past decades, microRNAs (miRNAs) have emerged as novel, prospective diagnostic and prognostic biomarkers in various illnesses, including ACS. We wanted to outline some of the most important studies in the field and address the possible utility of miRNAs in regulating particulate matter-induced ACS (PMIA) on inflammatory factors in this review.
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