Microbial degradation is considered as an attractive method to eliminate exposure to mycotoxin that cause a serious threat in agriculture global industry and severe human health problems. Compared with other more prominent mycotoxin compounds, fusaric acid (FA) biodegradation has not been widely investigated. In this study, a fusaric acid-degrading bacterium Burkholderia sp. IMCC1007 was identi ed by 16S rRNA gene sequencing and its detoxi cation characteristics were evaluated. This strain able to utilize FA as sole energy and carbon source with growth rate (µ) of 0.18 h − 1 . Approximately 93% from the initial substrate FA concentration was almost degraded to the residual about 4.87 mg L − 1 after 12 h of incubation. The optimal degradation conditions for pH and temperature were recorded at 6.0 with 30°Crespectively. An e cient FA degradation of strain IMCC1007 suggested its potential signi cance to detoxi cation development. Accroding to LC-MS/Q-TOF analysis, FA was bio-transformed to 4hydroxybenzoic acid (C 7 H 6 O 3 ) and other possible metabolites. Plant treated with detoxi ed FA products exhibited reduction of wilting index, mitigating against FA phytoxicity effect on plant growth and photosynthesis activity. Phytotoxicity bioassay suggested that degradation product of IMCC1007 was not a potent harmful compound towards plants as compared to the parent compound, FA. As a conslusion, our study provides a new insight into the practical application of biodetoxifcation agent in controlling mycotoxin contamination.
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